Memory抗原, CD8T淋巴细胞记忆Two seemingly unrelated hallmarks of memory CD8(+) T cells are cytokine-driven proliferative renewal after pathogen clearance and a latent effector program in anticipation of rechallenge. Memory CD8(+) T cells and natural killer cells share cytotoxi...
ARTICLES Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin Andrew M Intlekofer1, Naofumi Takemoto1, E John Wherry4,8, Sarah A Longworth1, John T Northrup1, Vikram R Palanivel1, Alan C Mullen1, Christopher R Gasink1, Susan M Kaech4,8, Joseph D Miller4, ...
CD38 Bright Effector Memory CD8+ T Cell Populations Predict Acute Graft Versus Host DiseaseChronic allograft rejectionInduced protein 8-like 2Novel biomarkerTumor necrosis factorTumor necrosis factor-ainduced protein 8-like 2 (TIPE2) has an essential role in immune homeostasis, yet the relationship ...
et al. Inflammation directs memory precursor and short-lived effector CD8+ T cell fates via the graded expression of t-bet transcription factor. Immunity 27, 281–295 (2007). Article CAS Google Scholar Martin, M. D. & Badovinac, V. P. Defining memory CD8+ T cell. Front. Immunol. ...
We addressed this by investigating whether the frequency of the CD8 T cell subsets and their phenotypic characteristics are altered in the peripheral blood and synovial fluid (SF) from patients with RA. In this study, CD8 T cells, mainly CD45RA effector memory (EM) CD8 T cells, were ...
Trafficking of CD8 T cells, in both the steady-state and during episodes of infection or inflammation, is a highly dynamic process and involves a variety of receptor–ligand interactions. A thorough, mechanistic understanding of how this process is regulated could potentially lead to disease preventi...
This proposed clinical impact of CD8 T memory cells among TIL is striking and obviously suggest their in situ function to be direct cancer cell killers. Accordingly, our current knowledge suggests that CD8 T cells seem to be more “simplified” in function compared to the CD4 T cells, and th...
clonally-expanded PD1-CD45RA+effector-memory CD8+T cells (CD8 TEMRA) with pronounced cytotoxicity. In contrast, in non-responders, CD8 TEMremain frozen in their effector-memory state. Finally, in responders, CD8 TEMRAdisplay a high degree of T cell receptor sharing with blood, consistent with ...
The precise pathways of memory T-cell differentiation are incompletely understood. Here we exploit transgenic mice expressing fluorescent cell cycle indicators to longitudinally track the division dynamics of individual CD8+ T cells. During influenza vir
Cutting Edge:Effector Memory CD8~+ T Cells Play a Prominent Role in Recall Responses to Secondary Viral Infection in the Lung and D.L. Woodland, Cutting edge: effector memory CD8+ T cells play a prominent role in recall responses to secondary viral infection in the lung. J ... AD Roberts...