effector function fc介导的效应器功能 effector function fc是免疫系统中一种重要的效应器功能,主要指由免疫细胞表面Fc受体结合抗体的Fc部分而产生的效应。 在免疫应答过程中,当抗原与特异性抗体结合时,抗体的Fc部分可以与免疫细胞上的Fc受体相结合,从而激活或增强免疫细胞的功能。 Fc受体主要存在于巨噬细胞、自然杀伤...
Fc region-containing polypeptides exhibiting effector function is improved by changing the fucosylated about the invention, and methods of using such polypeptides for the treatment or prevention of cancer and other diseases. Preferably, and comprises at least one amino acid substitution relative to the ...
Key Points Effector functions of γδ T cells influence the outcome of the host responses to infections, injury and malignancy, and they have a role in the pathology of allergic and autoimmune diseases. Although γδ T cells share functional features with other cells of the immune system, speci...
Tc CellsShort-chain Fatty Acids (SCFAs)Inhibit HDAC ActivityButyrate TreatmentThe gut microbiota produces metabolites such as short-chain fatty acids (SCFAs) that regulate the energy homeostasis and impact on immune cell function of the host. Recently, innovative approaches based on the oral ...
ENGINEERING FOR FcγR-BASED EFFECTOR FUNCTION Early studies defining key amino acid binding sites on IgGs for FcγRs were performed by mutational analyses, and it was determined that the lower hinge and proximal CH2 regions were critical (Burton et al.,1988; Canfield and Morrison,1991; Chappel...
These modified molecules confer an effector function to a molecule, where the parent molecule does not detectably exhibit this effector function. In particular, the molecules of the invention have an increased effector cell function mediated by a FcγR, such as, but not limited to, ADCC. In ...
Define effector. effector synonyms, effector pronunciation, effector translation, English dictionary definition of effector. n. 1. A muscle, gland, or organ capable of responding to a stimulus, especially a nerve impulse. 2. A nerve ending that carries i
A pathogen must prevent one of three stages of immune function: detection, activation, oreffectorfunction. 在侵染过程中,病原体必须逃避宿主三大免疫功能 之一: 检测 、 激活及效应功能. 互联网 In the myocardial fibrosis formation process, interstitialeffectorcells often play a crucial role. ...
To assess a key distal effector function as well as to address aspects of saturations and signal replacements, we recorded kinetics of IL-2 release in experiments of titrated dosages of anti-CD3, anti-CD28, and TCL1A in the iHH-TCL1A system. Although maximally stimulated levels of IL-2 we...
The transcription factors of the Rel/NF-魏B family function as key regulators of innate and adoptive immunity. Tightly and temporally controlled activation... A Visekruna,A Volkov,U Steinhoff - 《Clinical & Developmental Immunology》 被引量: 39发表: 2014年 A Key Role for NF-κB Transcription ...