Synergistic effects were observed with BEZ235 and Dox in both cell lines across a range of doses with median combination indices of 0.62 for SKLMS1 and STS39 (Fig. 5b). Synergy was observed during all three dosing schedules thus indicating that there is no difference between the treatment ...
These in vitro lines showed a range of sensitivity to standard chemotherapeutics, with varying expression levels of the prognostic markers hypoxia-induced factor (HIF) 1α and p53. Our evaluation of lead DIVERSet library compounds identified that JAG-6A, a compound that was significantly more ...
d Intrinsic fluorescence emission spectra were recorded in the range of 300 to 400 nm to determine the tertiary structure of the conjugate. All experiments were repeated three times independently. Statistical analysis was performed using one-way ANOVA, and significant differences were shown as P-...
Owing to successful cloning of wheat functional genes in recent years, more traits can be selected by diagnostic markers, and consequently, effective molecular markers will be powerful tools in wheat breeding programs. The present study proposed a cost-e
Oxidovanadium complexes with organic ligands are well known to have cytotoxic or differentiating capabilities against a range of cancer cell types. Their limited use in clinical testing though has resulted largely from uncertainties about the long-term toxicities of such complexes, due in part to the...
In recent years, some databases including numerous wheat KASP™ markers have been established, which will assist wheat breeders and scientists to select the most appropriate markers for MAS breeding [5,18]. CerealsDB version 3.0 is an online resource that contains a wide range of genomic dataset...
The X-ray diffraction (XRD) patterns were obtained by PHILIPS PW-1730 X-ray diffractometer (USA) with CuKα radiation (λ = 1.5418 Å) in the 2θ range of 10–80°. The optical charac- terizations were recorded using a UV–Vis diffuse reflection spectrophotometer (UV–Vis ...
The delivery of mRNA in the 41N PLV formulation with and without FAST protein was then assessed using a range of mass ratios of DODAP to mRNA. The highest expression of mRNA-FLuc in WI-38 cells was found at a DODAP:mRNA ratio of 3:1, and the incorporation of FAST protein significantly...
To realize the envisioned capabilities, the humanoid service robot is conceptualized with specific physical attributes, including a height range of 140 cm to 150 cm and a weight of 30 kg, with a robust payload capacity of up to 80kg. The design requirements for both the mobile platform and ...
A study of the cytotoxic activity of diacetoxyderivatives on the human mammary adenocarcinoma (MCF-7) and human colon carcinoma (HCT-116) cells was carried out using the MTT-test. It showed that the toxicity of the target compounds was absent or was insignificant throughout the range of ...