Uric acid (UA) has been proposed as an important risk factor for cardiovascular and renal morbidity. We conducted an interventional trial to assess effects of altered salt intake on plasma and urine UA levels and the relationship between UA levels and salt sensitivity in humans. Ninety subjects (...
High dietary salt, as well as renal mass reduction, is known to decrease baroreflex sensitivity in rats. However, the effect of high salt intake on baroreflex sensitivity is unknown in reduced renal mass (RRM) hypertension; therefore, the aim of this study was to investigate the effects of ...
Our aim was to assess the effects of the glucagon-like peptide-1 receptor agonist exenatide on heart rate (HR) and blood pressure (BP) in subjects with type 2 diabetes mellitus (T2DM). Methods: In this double-blind, placebo-controlled trial, subjects with T2DM on metfo...
Cardiovascular effects of glucose-lowering agents are of increasing interest. Our aim was to assess the effects of the glucagon-like peptide-1 receptor agonist exenatide on heart rate (HR) and blood pressure (BP) in subjects with type 2 diabetes mellitus
A colony of 26 chimpanzees given a fruit and vegetable diet of very low Na and high K intake were maintained in long-standing, socially stable small groups for three years. Half of them had salt added progressively to their diet during 20 months. This addition of salt within the human diet...
Objective:To sudy the effect of Salvia miltiorrhiza extract on heart rate and myocardial enzyme after myocardial ischemia/reperfusion injury in rats.Method:The SD rats were randomly divided into six groups(n=8,each):sham-operation group,model group,S.miltiorrhiza extract 12.8,6.3,3.2 mg·kg-1 gr...
Initially, patients were randomized in a 1:1:1:1 ratio to receive 12 weeks of treatment with 1 of 3 praliciguat doses (40, 20, or 10 mg daily) or placebo. The 40-mg dose was selected because drug levels in healthy participants were comparable to exposures in the Dahl salt-sensitive...
University of Toledo, Toledo, OH; Jack Kron, MD, Oregon Health & Science University, Portland, OR; Vikas Kuriachan, MD, Alberta Health Services, Alberta Canada; Owen Obel, MD, University of Texas Southwestern, Dallas, TX; Ravi Ranjan, MD, University of Utah, Salt Lake City, UT; Robert ...
Heart rate variability (HRV) is the instantaneous variation in heart rhythm due to autonomic influences on the sinoatrial node. Low HRV indicates high sympathetic- and low parasympathetic (vagal) autonomic activity, and is an established predictor of cardiac events [13] and mortality [14,15]. Not...
Diabetic kidney disease (DKD) is the most common disease among patients requiring dialysis for the first time in Japan. Multidisciplinary care (MDC) may prevent the progression of kidney failure. However, the effectiveness and timing of MDC to preserve k