Porras. 1987. Simulation of the effect of population size on the evolution of the recombination fraction. J. Theor. Bioi. 128: 399-405.Simulation of the effect of population size on the evolution of the recombination fraction - Alejandre-Duran, Andres-Cara, et al. - 1987...
Apolipoprotein E4 (ApoE4) is associated with an increased risk of Alzheimer’s disease (AD), depression, and anxiety, which were reported to improve after the administration of metformin. However, sex influence on the effect of ApoE4 and metformin on cog
improvement of mapping resolution by taking advantage of both historical and synthetic recombination, and the use of abundant genetic diversity without the effect of a population structure. The idea of using multi-parent populations in QTL analysis...
Of the eSNPs identified, 63 were also reported as meQTLs, indicating that the same SNP could simultaneously influence both DNA methylation levels and gene expression (Additional file2: Table S2 and Additional file5: Fig. S3B). The intricate mechanism underlying this dual regulatory role on gene...
In addition to the large effect size, these studies make it possible to model these variants and genes using cell and animal systems. On the other hand, the underlying population-variability of these very low allele frequency variants poses a great challenge to replicating results. Studies that ...
This locus is responsible for 3.6% of population variance in young adults and 2.5% of population variance in children. The effect size of the SORT1 locus is considerably higher in young populations (2.5– 4.1%) compared with older subjects (1%). (Pediatr Res 69: 538–543, 2011) Coronary ...
wheren= the number of observations. A value of .1 is considered a small effect, .3 a medium effect, and .5 a large effect. Phi is equivalent to the correlation coefficientr,as described inCorrelation. Phi is the measure of effect size that is used in power calculations even for continge...
Fifty-one study participants (30%) carried at least 1 APOEε4 allele (24 in the physical activity and 27 in the usual care control group). In a complete-case analysis of 18 months, there was a differential effect of exercise on ADAS-Cog scores according to APOEε4 carrier status, with...
Discussion In this study we evaluated the effect of SOD Ala16Val polymorphism on the ox-LDL-C levels in two age-different groups, a middle aged and an oldest old one. The allele frequency recorded in our populations was inversely distributed, compar- ing to Asians populations (current study:...
questions: (1) What is the effect of the receipt pattern of a favourable recessive gene immigrating each generation on the rate of gene substitution; (2) What is the effect of the receipt pattern of a detrimental recessive gene immigrating each generation on the equilibrium frequency of that ...