The effects of lidocaine have been investigated on electrical and contractile activity in guinea-pig ventricular cells in the absence and in the presence of ouabain. At low (therapeutic) doses, lidocaine induced a small reduction in action potential duration and contraction but had no effect on ...
Intracellular action potentials were recorded from normal canine Purkinje fibers using the standard microelectrode technique. The effects of lidocaine (2 and 5 mg/l), tocainide (10 and 20 mg/l) and verapamil (0.5 and 1.0 mg/l) on action potential characteristics as well as conduction times ...
compound action potentialperipheral nerve fibersLocal anesthetics, such as lidocaine chloride delay or inhibit the occurrence and transmission of impulses along the excitable tissue membranes, but there is not enough information about their effects on types of nerve fibers within the whole nerve. The ...
Injection of a small dosage of lidocaine (4 mg/kg body weight) failed to produce any significant change in ABR wave III, AP and CM. However, a large dosage of lidocaine (20 mg/kg) influenced ABR and AP, but had no observable effect on CM. Latency of ABR wave III was prolonged, ...
No significant effect on cell proliferation was found at lower concentrations (10 and 500 µM) of lidocaine or ropivacaine (Fig. 3). However, reduction in cell proliferation was found in both cell lines after exposure to the highest concentration (1,000 µM) of lidocaine and ropivacaine (...
We studied the effects of tetrodotoxin (TTX) and lidocaine on transmembrane action potentials and ionic currents in dog isolated ventricular myocytes. TTX (0.1-1 x 10(-5) M) and lidocaine (0.5-2 x 10(-5) M) decreased action potential dur... JA Wasserstrom,JJ Salata - 《American Journal...
Although lidocaine patch 5% has been widely used for postherpetic neuralgia, its analgesic effect on the intense pain associated with acute herpes zoster has not been investigated because of its potential hazard to damaged skin.MethodsForty-six patients suffering from moderate to severe pain caused by...
Step 2 included adjuvant oral medications (ie, nortriptyline, amitriptyline, gabapentin) and topical analgesics (ie, capsaicin, lidocaine). Step 3 included drugs requiring prior authorization from the VA clinic (ie, pregabalin, duloxetine) and tramadol. Patients were initially prescribed a step 1 ...
The effect of intranasal cocaine and lidocaine on nitroglycerin-induced attacks in cluster headache. Cephalalgia. 2000;20(2):85-91. doi:10.1046/j.1468-2982.2000.00026.xPubMedGoogle ScholarCrossref 30. Hannerz J, Jogestrand T. Chronic cluster headache: provocation with carbon dioxide breathing ...
A Comparison of the Hydrochloride and Carbon Dioxide Salts of Lidocaine and Prilocaine in Epidural Analgesia Philip R. Bromage Acta Anaesthesiologica Scandinavica Sep 1965 Lumbar epidural blockade has been used in a series of 659 patients to compare the analgesic properties of lidocaine and prilocaine....