Cholinergic transmission loss is one of the major features in Alzheimer's Disease (AD). Acetylcholinesterase inhibitors (AChEI) are moderately active in AD. α7nAChR (alpha-7 nicotinic acetylcholine receptor), encoded by CHRNA7 (Nicotinic Cholinergic Receptor Alpha-7 gene), is involved in ...
Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease We evaluated the effects of intranasal administration of the high-affinity iron chelator deferoxamine (DFO) on A尾 neuropathology and spatial learning ...
Intermittent Fasting Alleviates the Increase of Lipoprotein Lipase Expression in Brain of a Mouse Model of Alzheimer's Disease: Possibly Mediated by β-hyd... Intermittent fasting has been demonstrated to protect against Alzheimer's disease (AD), however, the mechanism is unclear. Histone acetylation...
Search ScienceDirect Outline Highlights Abstract Keywords 1. Introduction 2. Materials and methods 3. Results 4. Discussion CRediT authorship contribution statement Declaration of Competing Interest Acknowledgments Data Availability ReferencesShow full outline Figures (8) Show 2 mo...
Objective : The aim of this study was to examine the effects of the Home-based Multi-component Activity Program (Home-MAP) for the maintenance activities of daily living (ADL) for patients with mild Alzheimer's disease (AD) and on caregiver burden for caregivers. Methods : Nine mild AD ...
In three of the studies with cognitively impaired (including Alzheimer's disease (AD)) samples, the interventions had a beneficial effect on cognitive outcomes but only in participants with mild cognitive dysfunction [23, 25, 28]. This finding was not replicated in a large RCT conducted over 18...
Metabolic disturbances are linked to neurodegenerative diseases such as Alzheimer disease (AD). However, the cellular mechanisms underlying this connection are unclear. We evaluated the role of oxidative stress (OS), during early metabolic syndrome (MetS
Protective effect of resveratrol against corticosterone-induced neurotoxicity in PC12 cells Ye Zhang Ye Zhang School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, China; Department of Traditional Chinese Medicine, The Third People’s Hospital of Yunnan Province...
Abstract: A pharmacological study was made of the effects of various anticholinesterases (anti-ChEs) on the release of [3H]noradrenaline ([3H]NA) evoked by acetylcholine (ACh), nicotine, 56 mM K+, and veratridine from bovine adrenal chromaffin cells in culture. The anti-ChEs chosen were ...
The deposition of beta-amyloid (Aβ) aggregates in the brain, accompanied by impaired cognitive function, is a characteristic feature of Alzheimer’s disease (AD). An important role in this process is played by vascular disorders, in particular, a disturbance of the blood-brain barrier (BBB)...