plink1.9目前采用的是major与minor allele的概念,软件会自动计算频率,对原始数据进行操作时会自动改变allele的排序,如果你使用plink1.9 的—frq选项计算频率,你会发现输出的文件中是MAF ,minor allele frequency,不会高于0.5。 PLINK1.9中,A1为minor,A2为major allele,所以这里MAF是指A1(minor allele)的频率。 CHR SN...
Can an option be added to the main function to consider A1 as the effect allele instead? I have attempted to this manually, but it is inelegant without manipulating scripts contained within the MungeSumstats library.Owner Al-Murphy commented Jul 19, 2023 Hey! The easiest way to do this ...
因此,有必要研究等位基因的替代效应(effect of an allele substitution)。假定我们可以把随机挑选的等位基因A2变为A1,中选个体的基因型可能是A1A2也可能是A2A2,频率分别为p和q。把A1A2变为A1A1后,基因型值从d变为a,替换前后的效应变化为a-d;把A2A2变为A1A2后,基因型值从-a变为d,替换前后的效应变化为a+d...
【简答题】The effects of a dominant allele can be seen only when it is paired with another dominant allele. 查看完整题目与答案 【多选题】江南三大名廊是()。 A. 可园双面空廊 B. 沧浪亭复廊 C. 拙政园水廊 D. 网师园单面空廊 E. 留园曲廊 查看完整题目与答案 【多选题】...