脊椎动物 RNA聚合酶I 的启动子有两部分组成,包括转录起点附近的核心启动子 (core promoter) ,和起点 5'上游 100bp 左右的上游控制元件 (upstream control element,UCE) 。核心启动子从 -45 到 +20,负责转 录的起始。 UCE 从-180 延伸到 -107,此区可增加核心元件的转录起始的效率。 RNA Pol I需要2种辅助...
and has been an initiator, supporter and promoter of the UN Intergovernmental Expert Group on Cybercrime. China has actively facilitated the UN General Assembly’s adoption of a resolution to launch the negotiation process for a global convention on counterin...
In vertebrates, the dorso-ventral (DV) axis is defined by the combinatorial action of localised Wnt, FGF and Nodal signalling along with the antagonizing activities of Chordin and BMP pathways. Our knowledge of the factors that may act in concert with these core pathways to regulate early embryo...
The core promoter elements (INR, DPE, and TATA) were found in the regions flanking different 5′-untranslated exons, suggesting that these sequences (from 45 to +35) might be targeted as core promoters. The nucleotide identity rate of these core promoter sequences are different, and the ...
前rRNA基因转录起始点上游有两个顺式作用元件(cis acting element),一个是跨越起始点的核心元件(core element),另一个在–100bp处有上游调控元件(upstream control element,UCE)。RNA聚合酶I催化的转录需要2种转录因子,分别称为上游结合因子(upstream binding factor,UBF)和选择性因子1(selective factor1,SL1)。SL1...
The first total synthesis of (±)-jujuyane, a cyclooctanoid natural product, was accomplished from a (5 + 3) dimerization product of oxidopyrylium ylide that forms the cyclooctanoid core structure along with inherited stereochemical bias. Selective functional group modifications of the highly oxygena...