Overdose of edoxaban can increase the risk for major bleeding including intracranial and gastrointestinal hemorrhage. There is no specific antidote for edoxaban. Overdose and bleeding may be treated with discontinuation of the drug and appropriate symptomatic and supportive therapy. Severe interactions of e...
Currently, no antidote for edoxaban is available. To optimally prescribe agents in the DOAC class, it is critical that providers 1) understand how the agents compare and 2) identify specific settings where one agent may be preferred over another....
Furthermore, the feasibility of factor eight inhibitor bypass agent (FEIBA) as an antidote to modulate these DOACs is investigated. Materials and Methods Citrated pool blood plasma was obtained from Loyola blood bank. Purified thrombin was used as a trigger to generate clot at a concentration of...
A molecularly modified recombinant coagulation FXa, also known as Andexanet Alfa (AA), that has been developed as an antidote to neutralize the bleeding effects of oral FXa inhibitors, such as Apixaban and Rivaroxaban.#This study utilized thromboelastography (TEG 5000 Hemostasi...
To date, a specific antidote for edoxaban is not yet available. The management of ICH relies on the use of coagulation factors. This article reports a case of a 73-year-old woman with NVAF who had cerebral hematoma in the right intraparenchymal thalamus-capsular area while on therapy with ...