The group of inventions also concerns a pharmaceutical composition for the treatment of EDB+ FN-expressing malignant neoplasm containing the specified antibody-drug conjugate and a pharmaceutically acceptable carrier; a method for obtaining the specified antibody-drug conjugate. ;EFFECT: group of ...
ANTIBODIES AGAINST EDB AND ANTIBODY-DRUG CONJUGATES FIELD: medicine.;SUBSTANCE: group of inventions relates to medicine and concerns an antibody-drug conjugate for the treatment of a subject with an EDB+ FN-... ATU Hooper,KAU Marquette,CU Subramanyam,... 被引量: 0发表: 2021年 基于AutoCAD构建...
2021年04月26日患者至我科门诊就诊,查肝功能示转氨酶仍高,肝炎全套、铜蓝蛋白、抗线粒体抗体(anti-mitochondrialantibody,AMA)M2正常,肝胆胰脾彩超:肝脏弥漫性病变、门静脉高压超声改变,慢性肝纤维化检测提示肝脏硬度10.3kPa,脂肪衰减244dB/m,门诊予双环醇...
[0143]术语“人源化抗体(humanized antibody)”,也称为CDR移植抗体(CDR‑grafted antibody),是指将非人物种CDR序列移植到人的抗体可变区框架中产生的抗体。可以克服嵌合抗体由于携带大量异源蛋白成分,从而诱导的强烈的免疫应答反应。为避免在免疫原性下降的同时引起活性的下降,可对所述的人抗体可变区可进行最少反向突...
抗IL23A抗体(anti- IL23A antibody) 价格说明 价格:商品在平台的展示标价,具体的成交价格可能因商品参加活动等情况发生变化,也可能随着购买数量不同或所选规格不同而发生变化,如用户与商家线下达成协议,以线下协议的结算价格为准。 特别提示:商品详情页中(含主图)以文字或者图片形式标注的抢购价等价格可能是在特定...
We report the construction and the use of a phage display human antibody library (>3 x 10(8) clones) based on principles of protein design. A large reperto... A Pini,F Viti,A Santucci,... - 《Journal of Biological Chemistry》 被引量: 653发表: 1998年 FimH family of type 1 fimbria...
Antibody reactivity to human Factor Va, revealed in three animals, was not associated with FG application. Taken together, blood immunological and coagulation parameters support the suitability of salmon-derived FG in the development of fibrin sealants for medical use. 2009 Wiley Periodicals, Inc. J...
anti-thyroid antibody 抗甲状腺抗体 ATG antithyroglbulin 抗甲状腺球卵白 ATPase adenosine triphosphatase 三磷酸腺苷酶 BA bovine albumin 牛血清清卵白 BB buffer base 缓冲碱 BBb blood buffer base 血液缓冲碱 BBp plasma buffer base 血浆缓冲碱 BBs barbitone buffer solution 巴比妥缓冲碱 BCO blood carbon mo...
Here we developed an immunohistochemistry (IHC) assay to assess EDB+FN protein expression in the stroma of tumor and normal tissues to characterize the potential of EDB+FN as a therapeutic target for solid tumors with high unmet need. We validated a primary detection antibody and titrated assay ...
Treatment of cells exposed to high glucose with TGF-尾1 neutralizing antibody and ET receptor antagonist prevented high glucose-induced EDB + FN expression. In order to elucidate the functional significance of EDB + FN upregulation, cells were subjected to in vitro proliferation and angiogenesis ...