The target regions (total 1.9 Mb) are either whole genomic segments (17 regions) or only the coding part of genes (72 genes). DNA was collected from voluntary Italian subjects (41% male, 59% female), excludin
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(a) Venn diagram comparing total number of protein-coding genes found in randomly selected single-cell libraries (n=36) created with the MASC-seq and CEL-Seq single-cell approaches (n=36). (b) Barplot depicting number of unique protein-coding genes and transcripts found per single cell by ...
Whole-exome sequencing (WES) is powerful for dissecting the genetic basis of diseases as it targets all the protein-coding genes. Single nucleotide variations (SNVs) and insertions/deletions (InDels) are identified through WES. However, these techniques are costly, laborious, and time-consuming fo...
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