Ecto-nucleotidases are cell surface-located enzymes which catalyze extra-cellular nucleotide hydrolysis. An extracellular hydrolysis pathway for nucleotides has been detected in essentially all tissues and also in a large variety of cell culture systems. Its general features include the following: ...
Article: Ecto-nucleotidases and Ecto-phosphatases from Leishmania and Trypanosoma parasites
Ecto-nucleotidase biochemical activity of CD39 is lost at sites of acute vascular injury, such as in ischemia reperfusion and immune graft rejection. CD39L(Like)1/NTPDase2, a related protein, is associated with the basolateral surface of endothelium, the adventitia of vessels and microvascular ...
Recent evidence suggests that targeting adenosine by inhibiting ectonucleotidases may restore the resident antitumor immune response or enhance the efficacy of antitumor therapies. This paper will underline the impact of adenosine and ectonucleotidases on the antitumor response.BioMed Research International...
来源期刊 Clinical Biochemistry 1997/04/01 研究点推荐 Ecto-nucleotidases Biochemistry 站内活动 0关于我们 百度学术集成海量学术资源,融合人工智能、深度学习、大数据分析等技术,为科研工作者提供全面快捷的学术服务。在这里我们保持学习的态度,不忘初心,砥砺前行。了解更多>>...
Ectonucleotidases are ectoenzymes that hydrolyze extracellular nucleotides to the respective nucleosides. Within the past decade, ectonucleotidases belonging to several enzyme families have been discovered, cloned and characterized. In this article, we specifically address the cell surface-located members of...
Ectonucleotidases in Cancer and Inflammation doi:10.1155/2012/951423BioMed Research InternationalJohn StaggLinda F. ThompsonKaren M. Dwyer
We have investigated the stereoselectivity of ectonucleotidases (nucleoside triphosphatase, EC 3.6.1.15; nucleoside diphosphatase, EC 3.6.1.6; 5'-nucleotidase, EC 3.1.3.5) on pig aortic endothelial cells using two classes of nucleotide analogue. In experiments with nucleotide enantiomers in which the...
EctonucleotidasesHippocampusOvariectomyEstradiolAstrocytesPurinergic signaling is the main synaptic and non-synaptic signaling system in brain. ATP acts as a fast excitatory transmitter, while adenosine sets a global inhibitory tone within hippocampal......
Article: P2-purinoceptor antagonists: I. Blockade of P2-purinoceptor subtypes and ecto-nucleotidases by small aromatic isothiocyanato-sulphonates