ECL cells have many features in common with neurons and other peptide hormone-producing endocrine cells, including the ability to produce, store, and secrete chromogranin-A and chromogranin A-derived peptides. In addition, they produce and store histamine and respond with activation and growth to ...
Within the matrix, vWf is poised to bind to its ligand GP1b-IX-V on the surface of platelets, when the endothelial cells are disrupted upon vascular injury. The endothelial cells also secrete small amounts of vWf, in the form of high molecular weight multimers, constantly into plasma. ...
They have a typical ultrastructure and are uniquely able to produce, store, and secrete histamine.Duan ChenChun-Mei ZhaoRolf HkansonEncyclopedia of Endocrine DiseasesHakanson, R., Chen, D., and Sundler F. The ECL cells. In: Johnson, L.R., ed. Physiology of the Gastrointestinal Tract, ...
The present study describes the development of lipofuscin in the ECL cells of the rat stomach. These cells produce and secrete histamine in response to gastrin. They are rich in secretory vesicles, which fuse to form vacuoles in hypergastrinaemic rats. Hypergastrinaemia was induced by continuous...
Incubating ECL cells in the presence of interleukin-1 beta+bradykinin for 24 h reduced their ability to secrete histamine in response to gastrin. The inhibitory effect was reversed by 1 microM indomethacin. Also, increasing the concentrations of hydrocortisone in the medium resulted in an enhanced ...
1. Gastrin stimulates rat stomach ECL cells to secrete histamine and pacreastatin, a chromogranin A (CGA)-derived peptide. The present report describes the effect of nine cholecystokinin_2 (CCK_2) Receptor antagonists and one CCK _1 receptor antagonist on the gastrin-evoked secretion of Pancreas...
ECL cellsG cellsHistamineHistidine decarboxylase (HDCThe oxyntic mucosa of the rat stomach is rich in ECL cells which produce and secrete histamine in response to gastrin. Histamine and the histamine-forming enzyme histidine decarboxylase (HDC) have been claimed to occur also in the gastrin-...
The ECL cells are histamine-producing endocrine cells in the oxyntic mucosa that synthesize and secrete proteins and peptides. They are the primary target for gastrin and mediate the control of gastrin on acid secretion and oxyntic mucosal growth. Knowledge of the molecular biology of the ECL ...
Do ECL cells in the rat oxyntic mucosa secrete a calciotropic hormone?doi:10.1016/0167-0115(96)88089-XSurve V.VHakanson RELSEVIERRegulatory Peptides
We conclude that the gastrin-ECL-cell axis in the rat does not respond to peroral Ca2+. Since the ECL cells do not respond to either circulating or peroral Ca2+ they are unlikely to secrete a calciotropic hormone.doi:10.1016/S0167-0115(98)00002-0Vikas V Survé...