ECL cells exhibit functional impairment upon long-term gastrin stimulation. The impairment is manifested in a gradual decline of the activity of the histamine-forming enzyme per individual ECL cell and in a failure of gastrin to mobilize histamine. The mechanism behind this impairment is unknown. ...
ECL cells, histamine, gastrin, morphology, stomach, enterochromaffin, topology, gastrin stimulation, endocrine, paracrine,The term "enterochromaffin cell" was introduced more than 100 years ago. The cells that are morphologically similar to the enterochromaffin cells have been referred to as "enteroCurre...
Secretion of histamine from the ECL cells was studied in intact conscious rats subjected to gastric submucosal microdialysis and using isolated cells in primary culture. The microdialysis experiments revealed that ECL-cell histamine can be mobilized by the local infusion of gastrin, pituitary adenylate ...
Using immunohistochemistry at the conventional light, confocal and electron microscopic levels, we have demonstrated that rat stomach ECL cells store histamine and pancreastatin in granules and secretory vesicles, while histidine decarboxylase occurs in the cytosol. Furthermore the ECL cells display immunore...
ECL cells in the oxyntic mucosa of the mouse and rat stomach express CCK2 receptors, which enable them to respond to gastrin by the production and release of histamine. We have studied CCK2 receptor-deficient mice and rats subjected to pharmacological CCK2 receptor blockade in an attempt to ...
1 ECL cells express the enzyme histidine decarboxylase (Hdc) and, in response to neural and hormonal factors, they release histamine, which stimulates parietal cells to secret HCl. Interest in ECL cells greatly increased in the 1980s with the development of powerful acid-suppressive medications, ...
The ECL cells are the predominant endocrine cell population in the oxyntic mucosa. They produce histamine, chromogranin A/pancreastatin and an as yet unidentified peptide hormone. They respond to gastrin by the release of secretory products; more long-term responses include adaptation to the gastrin...
Von Willebrand factor is secreted as low molecular weight multimers constitutively into the extracellular matrix on the basilar surface of endothelial cells. Within the matrix, vWf is poised to bind to its ligand GP1b-IX-V on the surface of platelets, when the endothelial cells are disrupted ...
Histamine (HA), contained in the enterochromaffin-like (ECL) cells of the gastric mucosa in animals, plays an important role in gastric acid secretion, alt... Chun-Mei,Zhao,Gunilla,... - 《Cell & Tissue Research》 被引量: 85发表: 1997年 Gastric enterochromaffin-like (ECL) cells in hyper...
Eur J Gastroenterol Hepatol 10:927-931 (C) 1998 Lippincott Williams & Wilkins.doi:10.1016/S0016-5085(98)84860-9Zhao, C-MChen, DLindtunen, MPanula, PHkanson, RGastroenterology