In the current study, we address the biological function of a conserved miRNA, Bdo-Let-7 in the regulation of BdE75 gene, which belongs to the ecdysone signaling pathway and participates in the larval-pupal development in B. dorsalis. Using dual luciferase reporter assay in HEK293T cells we...
Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. ...
In Drosophila, ecdysone also coordinates programmed autophagy of larval fat body cells via downregulation of the PI3K, a principal player in the insulin signaling pathway (Rusten et al., 2004). While ecdysone is apparently sufficient for induction of starvation-induced autophagy, it remains unclear ...
which regulates the synthesis of hormones such as ecdysone. Ecdysone, a lipid-soluble steroid hormone, controls genes related to molting, metamorphosis, reproduction, and programmed cell death in insects [12,13,14]. Evidence indicates that the ecdysone signaling pathway also positively...
[2]. Minglei Lu, et al. Activation of Mineralocorticoid Receptor by Ecdysone, an Adaptogenic and Anabolic Ecdysteroid, Promotes Glomerular Injury and Proteinuria Involving Overactive GSK3β Pathway Signaling. Sci Rep. 2018 Aug 15;8(1):12225....
Surface glia are also involved in glucose metabolism required for neuron survival78 and SORL1, which is highly expressed here, enhances insulin receptivity79, suggesting that SORL1 promotes induction of the insulin signaling pathway in glial cells. Contrary to our initial expectations, some ...
The insulin/insulin-like signaling pathway (IIS) is a highly conserved nutrient-sensing pathway that serves various functions in metabolism, reproduction, longevity, cell size and, growth (reviewed inEdgar, 2006;Wu & Brown, 2006). IIS and its downstream target the TOR (target of rapamycin) path...
Here, we analyzed ecdysone-related gene expressionpatterns and found that they were consistent with a down-regulation of the ecdysone pathway being involved in the productionof winged offspring. We therefore predicted that reduced ecdysone signaling would result in more winged offspring. Experimental...
expression of different EcR isoforms is correlated with distinct cell and tissue responses toecdysone, suggesting that different ecdysone receptor forms contribute to the specificity of ecdysone signaling.In vivorescue experiments that show that the EcR isoforms are generally incapable of complete functional...
engulfment pathway blocks the clearance of dying salivary glands [91]. While all of this implicates a context-specific relationship between immune signaling component in mediating autophagy for cell death, the interconnection between ecdysone signaling, cell death and immune signaling needs further ...