EBV-positive lymphomaimmune escapeimmunodeficiencylymphoproliferative disorderPD-L1Background Epstein‐Barr virus (EBV) is detected in a variety of B‐cell lymphomas (BCLs) and B‐cell lymphoproliferative disorders (B‐LPDs). Immunodeficiency has been considered to play a key role in the pathogenesis ...
malignant lymphoma; inflammatory myofibroblastic tumour; florid lymphoid hyperplasia ; inflammatory polyp。 Essential and desirable diagnostic criteria Essential: Proliferation of atypical spindle to oval cells with indistinct cell borders, vesic...
T-cell lymphomaLYMPHOMASDIAGNOSISDIFFERENTIAL diagnosisThere may be significant histopathologic overlap between EBV﹑ositive DLBCL, NOS, and other diagnoses including angioimmunoblastic Tヽell lymphoma (AITL). Resolution of this differential diagnosis may be particularly challenging and require extensive ...
The development of B-cell lymphomas has been seldom described in HTLV-1 carriers. We present the case of an elderly Peruvian HTLV-1 carrier who was diagnosed with EBV-positive diffuse large B-cell lymphoma. Despite an initial good response to therapy, patient died during treatment due to fatal...
Epstein-Barr virus (EBV) is a human -herpesvirus that persists latently in the memory B-cell pool. EBV is linked to malignancies including Burkitt's lymphoma (BL) where it expresses specific latency genes. Among these genes, latent membrane protein (LMP)2A and LMP2B seem to be involved in...
Epstein-Barr virus–positive (EBV+) diffuse large B-cell lymphoma of the elderly (DLBCL-E), first described by Oyama et al,1,2 is a provisional entity in the 2008 World Health Organization (WHO) classification of lymphoid neoplasms,3 accounting for 3% to 14% of DLBCL cases.2,4, 5, 6...
The most common malignant subtype is post-transplant diffuse large B-cell lymphoma, which is positive for the Epstein–Barr virus (EBV) in the majority, but not all cases.1 This raises an important question: are EBV-positive (EBV+) and -negative (EBV−) post-transplant lym- phomas ...
DLBCL, NOS, anaplastic variant N Effaced Pan B markers+ Sinusodal or cohesive pattern Monotypic Monoclonal EBER-, CD30+ T-cell/histiocyte-rich large B-cell lymphoma N Effaced Pan B markers+ Scattered B cells in benign T cells/histiocytes background Monotypic Monoclonal EBER−, CD30+/−...
Isaacson P, Campo E, Harris N . Large B-cell lymphoma arising in HHV8-associated multicentric Castleman's disease. In: Swerdlow S, Campo E, Harris N,et al.(eds).WHO Classification. Tumours of Haematopoietic and Lymphoid Tissues, 4th edn. IARC: Lyon, 2008, pp 258–259. ...
Gastrointestinal (GI) lymphomas, though, can occur due to the immunosuppression caused by HIV, with diffuse large B-cell lymphoma (DLBCL) being common in this group. This case report describes a case of a patient ...