EBV-CTLs是可以特异性识别和杀伤EBV感染细胞的细胞毒淋巴细胞系,是生理条件下机体免疫系统抗病毒感染最重要成份。通常条件下,EBV的感染可以诱导机体产生细胞毒T淋巴细胞(cytotoxic T cells, CTLs)和辅助性CD4细胞,及时清除EBV转化的宿主细胞。CTLs通过细胞表面的T细胞受体,识别那些被EBV感染或转化的异常细胞,通过释放颗...
肿瘤传统治疗方式包括手术,化疗,放疗或者联合,过继性细胞免疫治疗是继传统治疗方式之后的一种新型肿瘤治疗模式.EBV-CTLs属于过继性免疫治疗的一种类型.本文就EBV-CTLs免疫治疗的分子基础,不同制备方式和临床应用,以及免疫检查点抑制剂增强EBV-CTLs抗肿瘤效应等相关研究进展进行综述,以期提高EB病毒感染相关性肿瘤患者的...
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摘要: Epstein-Barr病毒与人体多种肿瘤的形成有关,它在不同的肿瘤细胞上有不同的病毒基因表达谱.过继回输EBV-CTLs免疫治疗已取得显著疗效,但临床上仍存在诸多问题,本文主要介绍国内外EBV-CTLs治疗EB病毒相关性肿瘤的研究进展,并探讨PD-1阻断对EBV-CTLs抗肿瘤效应的作用....
EXPANSION OF EPSTEIN-BARR VIRUS (EBV)-SPECIFIC CYTOTOXIC T CELLS (CTLs) IN GAS PERMEABLE CELL CULTURE BAGSAn abstract is unavailable.doi:10.1097/00042560-199704010-00169J. M. DavisM. V. LemasR. OrentasL. L. EbyR. F. AmbinderJournal of Acquired Immune Deficiency Syndromes and Human ...
EBV specific T cell lines (EBV-T cell lines) were generated from normal individuals and XLP patients and examined for CTL function in response to different stimuli. It has been shown that XLP patients can generate EBV-T cell lines ... G Sharifi - University of London 被引量: 0发表: 200...
Diminished recognition of HLA-A2 proteins lacking a cytoplasmic domain (CY) by A2-restricted EBV-specific CTLs: possible role of the CY in TAP association Cannon,J M.,Osborn,... - IMMUNOGENETICS -NEW YORK- 被引量: 2发表: 1999年 Cytotoxic T Lymphocyte Response to Hepatitis C Virus-derived...
17 These studies have proved adoptive immunotherapy of EBV-CTLs as an effective strategy to reconstitute EBV-specific immunity and to treat EBV-associated malignancies. In this study, we aimed to evaluate the efficacy of EBV LMP1/2a CTLs as postremission therapy in ENKTCL patients. We ...
张樱子目前担任沅兮(台州)化妆品有限公司、台州路桥樱卉爱护肤馆等3家企业法定代表人,同时担任沅兮(台州)化妆品有限公司经理、执行董事,赫本(台州)医疗美容有限公司执行董事,经理;二、张樱子投资情况:目前张樱子是3家企业最终受益人,包括其在投资沅兮(台州)化妆品有限公司最终收益股份为50%,投资赫本(台州)医疗美容...
Currently, the antigen specificity of Epstein-Barr virus (EBV)-specific cytotoxic T cells (CTLs) can be determined using a set of recombinant vaccinia viruses expressing individual EBV proteins. Thesedoi:10.1385/1-59259-227-9:209Victor Levitsky...