Monoclonal antibody production by EBV transformation of B cells. WO/2004/076677. 2004 Sept. 10. Lanzavecchia A, inventors;Lanzavecchia, Antonio, " Monoclonal antibody production by EBV transformation of B cells, " not yet published U.S. Appl. No. 11/719,835, filed Feb. 26, 2004; Institute...
The EBV contig can help correct for artifacts stemming from immortalization of human blood lymphocytes with EBV transformation. It also captures endogenous EBV sequence since EBV naturally infects B cells in ~90% of the world population. 事实上,在 hg38 的 contigs 中,也有 chrEBV。这段序列的长度...
1996) of healthy individuals (>95% of the adult population). The infected B cells are all latent, but they are resting cells, not activated blasts (Miyashita et al. 1997). The periphery is a reservoir of persistent virus, since the absolute number of infected cells remains constant over ...
EBV lytic infection enhances transformation of B-lymphocytes infected with EBV in the presence of T-lymphocytes J. Med. Virol., 84 (2012), pp. 504-510 CrossrefView in ScopusGoogle Scholar Kim et al., 2009 V.N. Kim, J. Han, M.C. Siomi Biogenesis of small RNAs in animals Nat. Rev...
Epstein-Barr virus-encoded RNAs (EBER1 and EBER2) are two highly abundant, non-protein coding RNAs consistently expressed in all EBV infected cells, but their function remains poorly understood. Conventional in situ hybridization studies have indicated t
In DLBCL, LMP-1 is frequently expressed and plays a crucial role in the transformation of B cells. It activates the NFκβ, JNK, and p38 pathways by recruiting cellular TRAF 1-3 and TRADD molecules to 2 short sequence motifs CTAR-1 and CTAR-2 respectively, in the cytoplasmic domain of ...
EBV is a herpesvirus with demonstrated B-cell lymphotropism. EBV infection starts by attachment of the virus to the CD21 antigen; this initial step prepares the B-lymphocyte for EBV infection and is characterized by increased production of IL-6 and mRNA along with blastic transformation and mobil...
20. Kuppers, R. 2003. B cells under influence: transformation of B cells by Epstein-Barr virus. Nat Rev Immunol 3:801-12. 21. Laichalk, L. L., and D. A. Thorley-Lawson. 2005. Terminal differentiation into plasma cells initiates the replicative cycle of Epstein-Barr virus in vivo. ...
b cells under influence: transformation of b cells by epstein-barr virus. nature rev immunol. 2003, 3: 801-811. 10.1038/nri1201. article google scholar tierney rj, steven n, young ls, rickinson ab: epstein-barr virus latency in blood mononuclear cells: analysis of viral gene transcription ...
16 Overexpression of cyclin B1 promotes the G2/M phase transition, resulting in uncontrolled cell proliferation and even malignant transformation.17 Mitochondria have a unique function in virus-related tumorigenesis. Epstein–Barr virus (EBV) is an important oncovirus whose infection is widespread ...