1990年Burke应用PCR技术首次证明胃淋巴上皮瘤样癌(lymphoepithelioma-like carcinoma,LELC)中存在EBV感染。1993年Tokunaga等通过原位杂交技术证实胃癌细胞EBV编码的小RNA(EBV-encoded small RNAs,EBERS)阳性者,将之定义为EBV相关性胃癌(EBV-associated gastric carcinoma,EBVaGC ),其...
目的:胃癌(Gastric cancer,GC)是临床常见的恶性肿瘤之一,我国胃癌疾病负担较重,根据其不同特征可有多种分型.EBV相关胃癌(E pstein-Barr virus-associated gastric cancer,EBVa GC)是胃癌的特殊亚型之一,近年越来越多研究报道其可能存在相较其他类型胃癌独特的临床病理表现及预后特点,本研究旨在进一步明确并阐述EBVa ...
Due to the lack of prospective trials and limited understanding of the exact association between EBV and gastric cancer, testing for EBV status is not currently recommended for routine clinical care. 由于缺乏前瞻性试验和对 E...
Cancer Lett,2006, 238(1) :90鄄103. [30] 摇 Wiech T,Nikolopoulos E,Lassman S,et al. Cyclin D1 expression is induced by viral BARF1 and is overex鄄 pressed in EBV鄄associated gastric cancer[ J] . Virchows Arch,2008,452(6) :621鄄627. [31] 摇 Hino R,Uozaki H,Inoue Y,et al...
Epstein-Barr virus (EBV) plays an important role in gastric carcinogenesis and EBV infection is closely related to the development and progression of gastric cancer. Advances in molecular biology techniques have deepened our understanding of the characteristics of EBV-associated gastric cancer (EBVaGC)...
2023年3月21日,南京大学医学院何素素/李尔广团队在《Nucleic Acids Research》上在线发表了题为“LINE-1 repression in Epstein-Barr virus-associated gastric cancer through viral-host genome interaction”研究成果。这项工作从病毒与宿主...
2023年3月21日南京大学医学院何素素和李尔广团队在《Nucleic Acids Research》在线发表了题为“LINE-1 repression in Epstein-Barr virus-associated gastric cancer through viral-host genome interaction”的研究论文。该研究发现了EBV相关胃癌(EBVaGC)中LINE-1表达受抑制,尤其是位于内含子区域、进化年龄偏年轻、序列长...
·国家基金研 究进展 综述 · EBV相关性胃癌中EB病毒基因表达研究进展冰 杜云①② 俞霞① 季明芳① 摘要 EB病毒(Epstein—Barr virus,EBV)是 胃癌发生的生物学病 因之一 ,EBV相关性 胃癌(EBV associated gastric carcinoma,EB— VaGC)具有独特的临床病理学特征,其预后相对较好,因此EBV导致胃癌的机制研究也备受...
It is well understood that EBV can cause a variety of cancers in some patients, particularly immunocompromised hosts, including nasopharyngeal carcinoma, Burkitt lymphoma, Hodgkin's and non- Hodgkin's lymphomas, gastric carcinoma, ...
1.Atsushi Okabe et al. Cross species chromatin interactions drive transcriptional rewiring in Epstein Barr virus positive gastric adenocarcinoma. Nature Genetics, 2020, doi:10.1038/s41588-020-0665-7. 2.Epstein-Barr virus rewires h...