他们发现,一些人拥有针对EBV的抗体,这些抗体会错误地攻击大脑和脊髓中的一种蛋白。相关研究结果发表在2023年5月19日的Science Advances期刊上,论文标题为“Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis”。 作为一种疱疹病毒,EBV在生命早期感染大多数人,然后留在...
他们发现,一些人拥有针对EBV的抗体,这些抗体会错误地攻击大脑和脊髓中的一种蛋白。相关研究结果发表在2023年5月19日的Science Advances期刊上,论文标题为“Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis”。 作为一种疱疹病毒,EBV在生命早期感染大多数人,然后留在...
You show cross-reactivity with EBNA1/GlialCAM in serum samples of MS patients. In serum, it is well known that MS patients have a significantly higher antibody titer against EBNA1365-425, but the same trend has been harder to find in the CSF. Did you investigate CSF samples for the same...
The lower blot of a second gel run in parallel with the first, was probed with a MAb, PE2, reactive with EBNA2. Comparison of the two blots enables the EBNA1 and EBNA2 bands to be identified in the upper blot, and in this panel of cell lines it is apparent that the EBNA1 ...
Here we demonstrate high-affinity molecular mimicry between the EBV transcription factor EBV nuclear antigen 1 (EBNA1) and the central nervous system protein glial cell adhesion molecule (GlialCAM) and provide structural and in vivo functional evidence for its relevance. A cross-reactive CSF-derived...
EBNA1 specific CD4+ T cells of both healthy controls and MS patients were recently found to also react to the myelin autoantigen GlialCAM (Vietzen et al., 2023a). An additional cross-reactive CD4+ T cell specificity was identified for HLA-DRB1*1501 restricted peptides from the lytic EBV ...
Cytolytic CD4(+) T-cell clones reactive to EBNA1 inhibit Epstein-Barr virus-induced B-cell proliferation. J Virol. 2003;77:12088–104. PubMed CAS PubMed Central Google Scholar Sharifi R, Sinclair JC, Gilmour KC, et al. SAP mediates specific cytotoxic T-cell functions in X-linked ...
Recent studies have shown that EBNA1, in addition to EBNA3C and LMP1, promotes genomic instability and Ning Herpesviridae 2011, 2:1 http://www.herpesviridae.org/content/2/1/1 Page 6 of 11 reactive oxygen species (ROS)-mediated DNA damage response [61,62], and may facilitate c-myc ...
Recent studies have shown that EBNA1, in addition to EBNA3C and LMP1, promotes genomic instability and Ning Herpesviridae 2011, 2:1 http://www.herpesviridae.org/content/2/1/1 Page 6 of 11 reactive oxygen species (ROS)-mediated DNA damage response [61,62], and may facilitate c-myc ...
The hypothesis that EBV might cause CNS autoimmunity through molecular mimicry is supported by the identification of antibodies or T cells that cross-recognize peptides from EBV proteins (mainly EBNA1) and proteins expressed exclusively in the CNS or with a wider distribution (Lünemann et al., ...