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Ning RJ, Xu XQ, Chan KH, Chiang AK. Long-term carriers generate Epstein-Barr virus (EBV)-specific CD4(+) and CD8(+) polyfunctional T-cell responses which show immunodominance hierarchies of EBV proteins . Immunology . 2011; 134 ( 2 ):161–71. Epub 2011/09/08. doi: 10.1111/j.1365-...
EBNA-1在EBV基因组维持中必不可少,它是 唯一能在EBV感染的宿主细胞中持续表达的病毒蛋 白,可以阻止细胞处理和抗原呈递,使细胞毒性T 淋巴细胞不能识别自身免疫表位而逃避机体免疫应 答. 作为致癌基因,EBNA-1是EBVaGC潜 在的治 疗靶点.近年来已有以EBNA1为靶点治疗EBVaGC 的研究,但仍处于体外研究阶段[49,50]....
在感染的宿主中的复制期间,所述病毒表达大量抗原(即b细胞抗原),针对所述抗原可发展抗体,并将所述抗原分类为lydma(淋巴细胞识别膜抗原)、ebna(eb核抗原)、ema(早期膜抗原)、ea(早期抗原)、lma(晚期膜抗原)和vca(病毒衣壳抗原)抗原。这些类别的抗原本身包含多种抗原:例如,ebna类包含ebna-1、ebna-2、ebna-3a、e...
EBNA1 is expressed in all types of latency as well as lytic infection. Three fragments of EBNA1 protein, including 398-PPPGMRPP-404, 35-GPAGPRGGGRGR- GRGRGRGHNDGG-58, and 58-GGSGSGPRHRDG- VRR-72 mimics the self-antigens Sm B/B', Sm D1, and Ro, respectively, and therefore EBNA...
EBNA1 is expressed in all types of latency as well as lytic infection. Three fragments of EBNA1 protein, including 398-PPPGMRPP-404, 35-GPAGPRGGGRGR- GRGRGRGHNDGG-58, and 58-GGSGSGPRHRDG- VRR-72 mimics the self-antigens Sm B/B', Sm D1, and Ro, respectively, and therefore EBNA...
(nuclear antigen,NA)抗体产生 抗CA-IgG和抗NA-IgG可持续终生 5%新近EBV感染不出现CA-IgM抗体 在罕见的病例中抗CA-IgM会持续存在 约20-30%的新近感染不出现EA-IgG抗体 抗EBNA-IgG抗体可能呈现阴性,由于: - 慢性活动性EBV感染 - 细胞免疫被抑制 NA-IgG (+) CA-IgG(+)和EA-IgG(+)和/或CA-IgM(+)或...
EBNA1-specific CD4+ T cells in healthy carriers of Epstein-Barr virus are primarily Th1 in function. J Clin Investig. 2001;107:121–30. PubMed CAS PubMed Central Google Scholar Münz C, Bickham KL, Subklewe M, et al. Human CD4+ T lymphocytes consistently respond to the latent Epstein...
[EBNA 1, 2, 3A, 3B and 3C and EBNA leader protein (EBNA‑LP)], latent membrane proteins LMP-1 and LMP-2 (which encodes two isoforms, LMP-2A and LMP-2B), EBV-encoded small RNAs (EBER1 and EBER2) and microRNAs (miRNAs). During different stages of B cell differentiationin vivo, ...
YAC-1细胞类似产品::THLE-3细胞、Hu-P-T3细胞、THP 1细胞 Wistar Institute, Susan Hayflick细胞类似产品::HEK293-EBNA1细胞、RPMI-1846细胞、JROECL 21细胞 GM2219C细胞类似产品::AK细胞、HEK 293-EBNA细胞、Loucy细胞 RA.1细胞类似产品::TT细胞、H-1092细胞、COLO 680N细胞 ...