29. Icheva V, Kayser S, Wolff D, Tuve S, Kyzirakos C, Bethge W, et al. Adoptive transfer of epstein-barr virus (EBV) nuclear antigen 1-specific t cells as treatment for EBV reactivation and lymphoproliferative disorders...
这其中可以直接作为疫苗靶抗原的主要是EBNA和LMP两类蛋白,但由于EBV潜伏期又分为好几类,因此他们的表达也是在不同疾病和不同潜伏期有所区别。 Lawrence S. Young, Lee Fah Yap and Paul G. Murray. Epstein–Barr virus: more than 50 years old and still providing surprises. NATURE REVIEWS CANCER, 2016....
Cancer Sci, 2015, 106(11): 1576-1581. [24]JIANG X N, YU B H, YAN W H, et al. Epstein-Barr viruspositive diffuse large B-cell lymphoma features disrupted antigen capture/presentation and hijacked T-cell suppression [J]. Oncoimmunology, 2019, 9(1): 1683346. [25]DOJCINOV S D, ...
It may also be linked to Hodgkin lymphoma and some cases of stomach cancer. EBV-related cancers are more common in Africa and parts of Southeast Asia. Overall, very few people who have been infected with EBV will ever develop these cancers. https://www.cancer.org/cancer/risk-prevention/...
内核为缠绕双链 DNA的核心蛋 白 组成 ;衣核蛋 白为对称的20面体 ;包膜则是病毒释放 时包绕病毒的宿主细胞核膜 ,膜上有特异性糖蛋 白, 能够识别淋巴细胞 或上皮细胞 的EBV结合位点并介 导细胞融 合 ,形成潜 伏感染状 态 ,表达 EBV核抗原 (Epstein～Barr nuclear antigen,EBNA)、EBV潜伏膜蛋 白(1atent...
人淋巴细胞分离液Ficoll Plus1.077购自北京索莱宝生物技术公司;重组EBV核心抗原2(EBV nuclear antigen 2, EBNA2)蛋白购自美国Abcam公司;CD4+T细胞分选试剂盒、CD8+T细胞分选试剂盒购自德国美天旎公司;细胞计数试剂盒-8(cell counting ...
Cancer Sci,2010,101(1) :29鄄35. [27] 摇 Iwakiri D,Takada K. Role of EBERs in the pathogenesis of EBV infection [ J ] . Adv Cancer Res, 2010, 107: 119鄄136. [28] 摇 Wu Y, Maruo S, Yajima M, et al. Epstein鄄Barr virus ( EBV ) 鄄encoded RNA 2 ( EBER2 ) but not ...
Epstein-Barr virus strain variation and cancer. PMID: 30697862 Encyclopedia of EBV-Encoded Lytic Genes: An Update. PMID: 29896677 EBV Persistence--Introducing the Virus. PMID: 26424647 EBV Infection of Mice with Reconstituted Human Immune System Components. PMID: 26428383 ...
The final article discusses the therapeutic approach to EBV-associated LPDs. The clinical impact of EBV infection in cancer cells differs according to the tumor type. In Hodgkin’s lymphoma and EBV-positive DLBCL, the prognosis is poor in elderly patients but not in younger patients.30,31EBV-po...
(Janus kinase/signal transducer and activator of transcription,JAK/STAT)等信号转导通路的改变,以及免疫过程如干扰素应答,抗 原递呈系统和免疫检查点分子的异常等.这些基础研究成果促进了对相关治疗靶点的识别,有助于新治疗策略的探索.未来,嵌合抗原受体T细胞(chimeric antigen receptor T-cell,CAR-T)疗法,化疗联合...