structureVP40The matrix protein VP40 of the highly pathogenic Ebola virus (EBOV), a member of the filovirus family, is the most abundant protein in EBOV virions. During the viral life cycle it mediates assembly and budding from the host cell, and is responsible for the characteristic ...
Here we determined the structure of Ebola virus L protein in complex with tetrameric VP35 using cryo-electron microscopy (state 1). Structural analysis revealed that Ebola virus L possesses a filovirus-specific insertion element that is essential for RNA synthesis, and that VP35 interacts ...
Ebola Virus: Structure and Function from Chapter 7/ Lesson 16 25K Explore the characteristics of the Ebola virus, its structure, and the functions of its components. Discover why Ebola is a filovirus, how the virus creates its envelope, its genetic structure, and the role of glycoproteins in...
Filovirus proteins for antiviral drug discovery: a structure/function analysis of surface glycoproteins and virus entry. Antivir. Res 135, 1–14 (2016). Article CAS PubMed Google Scholar Lee, J. E. et al. Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor...
Ebola virus (EBOV) infection induces the formation of membrane-less, cytoplasmic compartments termed viral factories, in which multiple viral proteins gather and coordinate viral transcription, replication, and assembly. Key to viral factory function is the recruitment of EBOV polymerase, a multifunction...
7.2 Structure and Genome Ebola virus is one of the three Genre of the Family Filoviridae (Order Mononegavirales). Marburgvirus and Cuevavirus are the others two Genre. The prefix “Filo” suggests its filamentous shape (Kiley et al., 1982). Each Ebola virus carries a helical single-stranded ...
Ebolaviruses are highly dangerous pathogens exhibiting extreme virulence in humans and nonhuman primates. The majority of ebolavirus species, most notably ... YJ Ning,F Deng,Z Hu,... - 《Virologica Sinica》 被引量: 3发表: 2017年 Structure-function analysis of Ebola virus glycoproteins As a ...
Ebola virus (EBOV) entry requires the surface glycoprotein (GP) to initiate attachment and fusion of viral and host membranes. Here we report the crystal structure of EBOV GP in its trimeric, pre-fusion conformation (GP1+GP2) bound to a neutralizing antibody, KZ52, derived from a human sur...
Thus, broadly protective vaccines and antibody therapeutics for filoviruses are critically needed. Filovirus entry is mediated by the trimeric filovirus glycoproteins (GPs), which consist of disulfide-linked GP1 and GP2 subunits, with GP1 forming a chalice-like structure wrapped around by GP2 (Lee...
A third structure of VP40, formed by a different rearrangement, is not involved in virus assembly but instead uniquely binds RNA to regulate viral transcription inside infected cells. These results provide a functional model for ebolavirus matrix assembly and the other roles of VP40 in the virus...