Symptoms of EOTD typically develop first in an arm or leg in middle to late childhood and progress in approximately 30% of patients to other body regions (generalized dystonia) within about five years. Distribution and severity of symptoms vary widely between affected individuals. The majority of...
Treatment options include botulinum toxin injections for focal symptoms, pharmacological therapy such as anticholinergics (most commonly trihexiphenydil) for generalized dystonia and surgical approaches such as deep brain stimulation of the internal globus pallidus or intrathecal baclofen application in severe...
Parkinson’s disease early symptomsmay be subtle, go unnoticed and develop gradually over a number of years. A person will often feel ‘out of sorts’ and unable to pinpoint what exactly is wrong with them. It is not uncommon at this stage, for a patient to visit their practitioner and ...
In some patients, Parkinson’s causes other motor symptoms, including vision problems such as blurred vision or difficulty looking up, painful muscle cramps (dystonia), and difficulty maintaining an upright posture which can lead to stooping and abnormal curvature of the spine (scoliosis or kyphosis...
Functional neurological (conversion) disorder (FND) is a neuropsychiatric condition whereby individuals present with sensorimotor symptoms incompatible with other neurological disorders. Early-life maltreatment (ELM) is a risk factor for developing FND, yet few studies have investigated brain network–trauma...
Mutations in THAP1 (DYT6) and generalised dystonia with prominent spasmodic dysphonia: a genetic screening study. DYT6 is a primary, early-onset torsion dystonia; however, unlike in DYT1 dystonia, the symptoms of DYT6 dystonia frequently involve the craniocervical regi... A Djarmati,SA Schneide...
抗精神病药物治疗早期最常见的不良反应(Antipsychotic treatment was the most common adverse event in the early stage) 5.3.3.1.1 over sedation The most common adverse effects of antipsychotic treatment are sedation, weakness, and dizziness, with a prevalence of more than 10%. Chlorpromazine and chlorin...
Indeed, non-motor symptoms, such as pain, sleep problems, cognitive deficits and psychiatric problems, have been found in dystonia patients [5,6,7,8,9,10]. Research in adult and childhood dystonia patients has shown that these non-motor symptoms predict health-related quality of live (HR-QoL...
Individuals with early-onset and childhood-onset schizophrenia experience psychotic symptoms before ages 18 and 13 years, respectively [4]. Childhood-onset schizophrenia is considered to be an especially severe form of psychosis, with a higher rate of brain abnormalities as well as greater ...
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