B cell chronic lymphocytic leukemia (CLL) also called chronic lymphocytic leukemia is a disease of elderly, but in rare cases it can occur in young adults. Majority of patients present with no specific symptoms, and CLL is suspected on the basis of high total and relative lymphocyte counts, ...
We report a randomized prospective phase 3 study (CLL7), designed to evaluate the efficacy of fludarabine, cyclophosphamide, and rituximab (FCR) in patients with an early-stage high-risk chronic lymphocytic leukemia (CLL). Eight hundred patients with untreated-stage Binet A disease were enrolled ...
The definition of CLL relies on the absolute count of ≥ 5 × 109leukemic cells/L in the blood. Cases with nodal, splenic, or extramedullary involvement but less than this degree of lymphocytosis are termed SLL. The malignant cell type is the same. Virtually all cases of CLL are ...
In March 2006, the biologic drug theralizumab (TGN1412) underwent trials as a CD28 “superagonist” intended for the treatment of B cell chronic lymphocytic leukemia (B-CLL) and rheumatoid arthritis. The drug was administered as an intravenous infusion to the first healthy volunteer in its cli...
Symptoms of low blood cell counts are common during treatment with LYNPARZA, but can be a sign of serious bone marrow problems, including MDS or AML. Symptoms may include weakness, weight loss, fever, frequent infections, blood in urine or stool, shortness of breath, feeling very tired, br...
Lump in the testicle.A painless one is a possible warning sign of testicular cancer. Yet the bump could also be from an injury, fluid buildup, or a hernia. It's hard to tell the cause from your symptoms alone, so go to your doctor for an exam. ...
This was found to stabilize in the adjuvant setting; the mean values in both cohorts at visits through cycle 16 were comparable to those reported at baseline for most of the symptoms assessed, with the exception of fatigue. “It might suggest that there was not a complete stabiliza...
SYMPTOMSCHRONIC lymphocytic leukemiaSummary: Most patients with chronic lymphocytic leukaemia (CLL) are nowadays diagnosed without any symptoms and do not require therapy. A prognostic score identifying patients within this large group who are at high risk of disease progression would be highly b...
Here, we report a case of cryptococcal meningitis occurring early after initiation of treatment with rituximab, fludarabine and cyclophosphamide (R-FC) in a patient with chronic lymphocytic leukemia (CLL).Leukemia and lymphoma
3 cohorts of 3 (A), 3 (B) and an extended cohort of 27 (C) patients with relapsed or refractory chronic lymphocytic leukemia (B-CLL) received 4 weekly i.v. infusions of HuMax-CD20 and will be followed for 12 months. The first infusion administered was 100 mg, 300 mg and 500 mg ...