BOB EDWARDS
During systemic anthrax, late stage events include vegetative growth in the blood to very high titres and the synthesis of the anthrax exotoxin complex, which causes disease symptoms and death. Experiments focus on the early events occurring during the first few hours of the B. anthracis ...
Also, pathogens with GCBR potential are believed to spread during incubation before the onset of solid symptoms [32]. In terms of origin, most human infectious diseases (58–65%), including COVID-19, are zoonotic pathogens, and many of the pathogens that cause severe amplifications in ...
2,3,4]. The first vaccines were live-attenuated vaccines (LAVs), obtained by the attenuation of virulent infectious agents [5]. Louis Pasteur formulated the idea of attenuation, performed the famous anthrax challenge experiment in cattle at Pouilly...
acute hemorrhagic syndrome (AHS), acute neurologic syndrome (ANS); seven suspected cases: tetanus, neonatal tetanus, pertussis, diphtheria, anthrax, plague and rabies; and four special events: FDs, nosocomial infections (NIs), adverse events following immunization and unexplained clusters of health eve...
Temporal trends, usually measured through one-dimensional scan statistics[36, 41, 42] are of interest to monitor general patterns of symptoms. This is of particular interest for unusual events where a few cases would result in a likely alert (e.g. anthrax). Spatial clustering analysis, using ...
The technique promises to detect the earliest stages of infection before any other laboratory or radiographic diagnostic test and well before serious symptoms of the infection are apparent. The trial is designed to identify asymptomatic patients who experience "credible exposure" to anthrax spores. For...
But doctors can be slow to recognize diseases like anthrax, which, in its early stages, mimics the flu. One key to rapid—and accurate—diagnoses is to quickly identify patterns that a single doctor might miss: clusters of patients with similar symptoms. The other hurdle is finding an easy ...
CUTANEOUS ANTHRAXBACKGROUND: Switch therapy is defined as the early transition from intravenous to oral antibiotics during treatment of infection. This study was designed to evaluate the clinical outcome and length of stay of hospitalized patients with community-acquired pneumonia treated with an early ...
Biological agents such as anthrax and viral hemorrhagic fever may present symptoms in the human population in a similar manner as more common illnesses such as a cold or flu. As a result, a bioterrorism attack that uses one of these biological agents would be difficult to quickly distinguish ...