In the Cox multivariate model, age, progression rate of respiratory, bulbar, and lower limb symptoms, EEDC classification, percutaneous endoscopic gastrostomy, and treatment with riluzole were significantly related to outcome.The rate of progression of symptoms in early ALS is...
ALS is no exception; its incidence (male: female ratio 3:1) and prevalence are higher in men than in women, with a predominance of men with younger dis- ease onset. Clinical phenotypes are also different in male and female patients, especially regarding the site of onset of weakness, as ...
Symptoms of Fabry disease in the pediatric population are well described for patients over five years of age; however, data are limited for infancy and early childhood. The purpose of this article is to delin- eate the age of detection for specific Fabry symptoms in early childhood. Methods: ...
Hence, in males, forebrain CRH signaling during development may be sufficient to induce the 'double hit' phenomenon, in which early-life stress interacts with adult trauma to induce PTSD-like symptoms. Moreover, early-life CRHOE led to lasting increases of arousal indexed by startle reactivity ...
“NfL won’t ever, on its own, be a diagnostic biomarker for any of the neurodegenerative diseases,” explains Dr. Tania Gendron, an FTD researcher at the Mayo Clinic. “However, there are some diseases, like FTD or ALS, that have symptoms that might be mimicked by other diseases that ...
Aiken, 54, said his ALS symptoms in his legs went into remission after he was treated on August 7 with the fourth in a series of epidural steroid injections he received for lower back and leg pain. Just two days earlier, doctors at Weill Cornell Peripheral Neuropathy Center had found fascic...
Breast cancer is the most prevalent disease for women. With advances in breast cancer screening, most breast cancers are now diagnosed in the early stages. With knowledge of different subtypes and their behavior, breast cancer treatment has become more individualized. Radiation therapy as one of the...
The fact that the findings in humans mirror those in rats may establish a relationship between the observed changes and alcohol consumption, which is difficult to verify based on human results only, given the large heterogeneity of the abuse patterns, medication for relief of withdrawal symptoms, ...
www.nature.com/scientificreports OPEN received: 08 December 2015 accepted: 12 April 2016 Published: 28 April 2016 Histone Modifications in a Mouse Model of Early Adversities and Panic Disorder: Role for Asic1 and Neurodevelopmental Genes Davide Cittaro1, Valentina Lampis2, Alessandra Luchetti...
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