The pathologic lesions associated with AD develop many years before the clinical manifestations of the disease become evident, during a likely transitional period between normal aging and the appearance of first cognitive symptoms. AD biomarkers are needed not only to reveal these early pathologic ...
Dementia Prevention Starts Early in Life More than 747,000 people in Canada are living with some form of dementia, with the numbers continuing to grow as the baby boom population grows older. Yet today, the individual risk of developing dementia is half of what it was only forty years ago....
Given the indolent progression of dementia, one concern is the possibility of reverse causality. Patients already experiencing subtle but undiagnosed symptoms of cognitive decline might be more likely to attend one of these AWVs, or caregivers might proactively arrange such appointments for pat...
Risk assessment and primary prevention of Alzheimer disease. CMAJ 178:548–556 Google Scholar Penn DL, Kohlmaier JR, Corrigan PW (2000) Interpersonal factors contributing to the stigma of schizophrenia: social skills, perceived attractiveness and symptoms. Schizophr Res 45:37–45 Google Scholar ...
Predictive accuracy of the extended Predementia Alzheimer disease Scale (PAS) for Alzheimer-type dementia in subjects with MCI Pieter Jelle Visser, Niki Schoonenboom, Jaap Lindeboom, Femke Bouwman, ... Philip Scheltens Page S12 select article Plasma AB levels as a premorbid biomarker for cognitive...
Early Therapy for Symptomatic COPD, Asthma Improved Quality of Life Emily Harris JAMA. 2024;332(2):97. doi:10.1001/jama.2024.10342 Full Text Despite experiencing symptoms, roughly 70% of people with chronic obstructive pulmonary disease (COPD) and asthma do not know they have the condition....
The symptoms of Alzheimer disease reflect a loss of neural circuit integrity in the brain, but neurons do not work in isolation. Emerging evidence suggests that the intricate balance of interactions between neurons, astrocytes, microglia and vascular cells required for healthy brain function becomes pe...
Early intervention in psychosis is a clinical approach to those experiencing symptoms of psychosis for the first time. It forms part of the new prevention paradigm for psychiatry and is leading to reform of mental health services, especially in the United Kingdom. There has been considerable academ...
Accurate diagnosis of Alzheimer’s disease (AD) in its earliest stage can prevent the disease and delay the symptoms. Therefore, more sensitive, non-invasive, and simple screening tools are required for the early diagnosis and monitoring of AD. Here, we
symptoms after mTBI. Indeed, we suggest that the emergence of proteinopathy may be a result of some or all of these early pathogenic processes and loss of protective mechanisms and, because these changes occur very early, they may represent viable treatment targets for the prevention of long-...