Background/aims:Gut-barrier dysfunction is well recognized in pathogenesis of both non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). However, comparison of components of this dysfunction between the two etiologies remains unexplored especially in early stages of NAFLD. ...
These findings suggest that HMGB1, particularly when it comes to individuals in the early and advanced stages of DN, may accurately monitor the status of the disease. Download: Download high-res image (636KB) Download: Download full-size image Figure 6. The diagnosis values of HMGB1 in DN ...
Nonalcoholic fatty liver disease (NAFLD) is a common metabolic disease that affects 20–30% of individuals worldwide. Liver puncture remains the gold standard for the diagnosis of liver diseases despite limitations regarding invasive nature and sample variability. It is of great clinical significance ...
the roles of p53 in the pathogenesis of DCM at later stages of diabetes have never been examined. Recent studies indicated that p53 has broader roles, which include its metabolic regulation in cells under both adaptive physiologic and pathologic disease conditions14. One ...
(D5D), responsible for the conversion of a.o. dihomo-gamma linoleic acid into arachidonic acid (Fig.2, 3. Linoleic acid metabolism), has previously been observed reduced in diverse metabolic disorders, e.g. non-alcoholic fatty liver disease, and has been associated with underlying IR and ...
1 The presence of early stages of atherosclerosis in fetuses and youth indicates the potential importance of adopting preventive measures at very early stages of human development.2-4 Moreover, cardiovascular risk factors may be associated with atherosclerotic disease at a young age, and maternal ...
The risk for cancer in patients with nonalcoholic fatty liver disease (NAFLD) was highest among those with early-onset disease and declined at later ages of diagnosis, a matched cohort study found. Examining more than 60,000 participants from a prospective Chinese dataset revealed that the increas...
The expression of hypoxia-immune-related DEGs of specimens from different stages of cirrhosis were compared. The clinical data of the individuals are presented in Table 6. The levels of direct bilirubin, indirect bilirubin, and total bilirubin were higher in patients with liver failure than in pati...
Much attention was therefore paid to identification of urinary biomarkers of the early stages of the nephrotoxicity of these metals [54]. Oxidative stress has been termed as cause and effect in heavy metal-induced kidney toxicity and is suggested to play a key role in the early process of ...
Ultrasonography is a noninvasive tool to examine the liver parenchyma. The aim of the current study is to evaluate the accuracy of ultrasonography in combination with fibroblast growth factor 21 (FGF21) in early detection and diagnosis of NAFLD, especially early stages (m...