Despite major improvements in the treatment of early-stage breast cancer over the past 15 years, many controversies exist surrounding the optimal adjuvant therapies for these patients. Adjuvant chemotherapy has been demonstrated to reduce recurrence and improve mortality, but questions persist as to what...
“The addition of immunotherapy to chemotherapy definitely improves outcomes for patients with early-stage triple-negative breast cancer, but it does come at the cost of toxicity,” Dr. Sharma acknowledged. Immune-related adverse events of any grade have been reported in up to 44% of patients wi...
Roubidoux MA, Le Carpentier GL, Fowles JB et al (2005) Sonographic evaluation of earlystage breast cancers that undergo neoadjuvant chemotherapy. J Ultrasound Med 24:885–895Sonographic evaluation of early-stage breast cancers that undergo neoadjuvant chemotherapy. Roubidoux, Marilyn A.,LeCarpentier...
NEW YORK, June 4 (Xinhua) -- A new study has found that about 70 percent of women with the most common form of early stage breast cancer may avoid gruelling chemotherapy and still enjoy a similar survival rate. The study, published Sunday in the New England Journal of Medicine, enrolled ...
In early-stage breast cancer, tumor gene-expression assays can be used to determine the likelihood of recurrence and thus the potential benefit of adding adjuvant chemotherapy to endocrine therapy. Commercially available assays have demonstrated efficacy for this in women with hormone-receptor (HR)–po...
EP: 15.What is on the Horizon for Adjuvant Therapy in Early-Stage Breast Cancer?Transcript: Stephanie Graff, MD, FACP: Let’s fast-forward with this patient and assume that she has gone through adjuvant chemotherapy and radiation, and is presenting to discuss initiation of adjuvant endocrine th...
and then using RSClin. And where RSClin I think is going to be most helpful is for those patients who have a score of like 26, 27 where we really don’t have good information about whether we should be using chemotherapy, and estimators for benefit from chemotherapy. I too have logged...
In vivo chemosensitivity-adapted preoperative chemotherapy in patients with early-stage breast cancer: the GEPARTRIO pilot study. BACKGROUND: Response to the first two cycles of preoperative chemotherapy might differentiate subgroups of breast cancer patients with high or minimal cha... GV Minckwitz,JU...
Case 1: Approach to Early Stage, HER2+ Breast Cancer Case 4: Chemotherapy or PARP inhibitors for BRCA+ TNBC Case 4: PARP Inhibitors for Treating BRCA+ Triple-Negative Breast Cancer Case 4: OlympiAD Trial for BRCA+ Metastatic TNBC Case 4: BRCA+ Metastatic Breast Cancer Case 3: Treatment Afte...
Some Postmenopausal Women With Early-Stage Breast Cancer on Hormone Therapy Can Forego Chemotherapy Clinical Breast CancerKalinsky, Kevin