Triple-negative BC (TNBC), constituting about 20% of BC, does not express ER or PR receptors and is HER2-negative. They are commonly seen in women below 40 years of age, mainly in African-American women. Subgroups include- claudin-low, basal-like (BL1 and BL2), luminal androgen receptor...
In the early stages of TNBC, neoadjuvant chemotherapy (NAC), which is given to the patient before surgery, has been considered a viable treatment strategy. Pathological complete response (pCR), which has been shown to increase estimates of disease-free (the amount of time following treatment ...
6. Tuan NM, Nhan HT, Chau NVV, Hung NT, Tuan HM, Tram TV, Ha NL, Loi P, Quang HK, Kien DTH, Hubbards S, Chau TNBC, Wills B, Wolbers M, Simmons CP. Sensitivity and specificity of a novel classifier for the early diagnostic of dengue. PLoS Negl Trop Dis. 2015;9(4):e0003638...
EGCG also acts by downregulating the expression of anti-apoptotic genes like insulin-like growth factor1 receptor (IGF1R) and myeloid cell leukaemia sequence 1 (MCL1) and arrests the breast tumor invasion in TNBC by inhibiting the expression of vascular endothelial growth factor (VEGF). Apart from...
It may be used with chemotherapy medicines as treatment before surgery and then continued alone after surgery when you have early-stage breast cancer, and are at high risk of your breast cancer coming back (high-risk early-stage triple-negative breast cancer [TNBC]). It may be used with che...
It may be used with chemotherapy medicines as treatment before surgery and then continued alone after surgery when you have early-stage breast cancer, and are at high risk of your breast cancer coming back (high-risk early-stage triple-negative breast cancer [TNBC]). It may be used with che...
Abbreviations: HR:hormone receptor,TNBC: triple negative breast cancer. Created withBioRender.com. 2. Breast cancer treatment 2.1. Local therapy Routine use ofsentinel lymph node biopsy(SLN) has allowed many patients to safely avoidaxillary lymph nodedissection (ALND) and its associated morbidity [[...
Among these, 50.0% were luminal A, 25.0% were luminal B, 10.7% were HER2-enriched and 14.3% were triple-negative breast cancer (TNBC). These subtypes showed distinct differences in the times from primary diagnosis to detection of distant metastasis (RFS). As shown in Figure 3, the survival...
T2 219(65.3 %) TNBC 66(19.7 %) T3 52(15.5 %) pCR T4 19(5.6 %) No 247(73.7 %) cN stage Yes 88(26.2 %) N0 27(8.0 %) FPG,mg/dl, median (IQR 25–75) 91.8(86.4–102.6) N1 148(44.1 %) TC,mg/dl, median (IQR 25–75) 179.4(154.7–206.1) N2 92(27.4 %) TG,mg/dl,...
In the U.S., KEYTRUDA has two approved indications in TNBC: for the treatment of patients with high-risk early-stage TNBC in combination with chemotherapy as neoadjuvant treatment, and then continued as a single agent as adjuvant tr...