Teclistamab-cqyv (Tecvayli) in combination with talquetamab showcased early signs of activity with acceptable safety in patients with relapsed/refractory multiple myeloma, according to final results from the phase 1b RedirecTT-1 study (NCT04586426) presented at the 2023 ASCO Annual Meeting...
“At [100 μg/kg] every 3 weeks, [HDP-101] demonstrated in penta-refractory multiple myeloma an overall response rate of technically 50%, with 3 responding patients of 6 in this dose cohort,” Raab said in the presentation. The phase 1 trial will proceed with additional sched...
What are the first signs of cancer? The first signs depend on the type of cancer. The first sign of breast cancer might be a painless lump in the breast. A nagging cough might be the first sign of lung cancer. A sore inside your mouth could be a sign of oral cancer. But all of ...
The administration of Chimeric Antigen Receptor T-cell (CAR-T) therapy for relapsed refractory multiple myeloma (RRMM) predominantly takes place in the inpatient setting to monitor for adverse effects like cytokine release syndrome (CRS) and neurotoxicity leading to increased healthcare utilization, ...
In 13.6% (6/44) of patients, secondary malignancies besides breast cancer were detected: two ovarian (Figure 2B), one uterine, one gastric, one lung, one parotid cancer and one multiple myeloma (Table 3). One patient had both local recurrence and a secondary tumour. Of the patients, 22.7...
Increased Mortality in Patients with Multiple Myeloma when OPDIVO is Added to a Thalidomide Analogue and Dexamethasone In randomized clinical trials in patients with multiple myeloma, the addition of OPDIVO to a thalidomide analogue plus dexamethas...
A pCR rate is defined as a lack of all signs of cancer in tissue samples analyzed following completion of neoadjuvant therapy and definitive surgery (ypT0/Tis ypN0). The trial is currently continuing without ch...
Increased Mortality in Patients With Multiple Myeloma In trials in patients with multiple myeloma, the addition of KEYTRUDA to a thalidomide analogue plus dexamethasone resulted in increased mortality. Treatment of these patients with an an...
Both lines of KCS mice were born with expected Mendelian frequency. While CS mice with Sag transgenic expression without KrasG12D did not show any abnormality up to adulthood, the KCS mice started to show the signs of growth retardation with a hunched-posture after 4-5 months of age. We...
Men with prostate cancer were twice as likely to have signs of alopecia at age 20 compared with controls without prostate cancer. Yassa and colleagues said that while androgens appear to be implicated in the development of male pattern baldness and prostate cancer, a direct link between the 2 ...