Aims: Multiple system atrophy (MSA) is a fatal neurodegenerative disease that belongs to the family of alpha-synucleinopathies. At post mortem examination, intracellular inclusions of misfolded alpha-synuclein are found in neurons and oligodendrocytes and are considered to play a significant role in ...
Objective: We aim to search for predictors of survival among clinical and brain 18F-FDG positron emission tomography (PET) metabolic features in our cohort of patients with multiple system atrophy (MSA). Methods: We included patients with a 'probable' MSA diagnosis for whom a clinical evaluation...
Shy-DragersyndromeThe clinical features and natural history of 100 patients diagnosed as probable multiple system atrophy (MSA) are described. In all 14 (... G.,K.,Wenning,... - 《Brain》 被引量: 706发表: 1994年 History of syncope in the cardiac literature. of patients with these entitie...
During early stages of disease, these assessments can fail to distinguish classic PD from other synucleinopathies such as multiple system atrophy (MSA), and from non-αSyn-driven forms of parkinson- ism, such as progressive supranuclear palsy (PSP) or cor- ticobasal degeneration (CBD). ...
All patients were followed for at least five years to ensure none of the other patients developed signs of MSA or another atypical parkinsonian syndrome. 16 PD patients were lost to followup, two had progressive supranuclear palsy, one had dementia with Lewy bodies, and one had an uncertain ...
Some signs of such accumulation in rat soleus muscle after HS were observed by Wakatsuki et al. [17] using NMR spectroscopy. It should also be expected that a direct consequence of ATP accumulation and a corresponding decrease in AMP can be a decrease in the phosphorylation...
The MS-VAR model is divided into MSI-VAR (intercept change), MSM-VAR (mean change), MSA-VAR (autoregressive parameter change), MSH-VAR(there is heteroscedasticity) and other specific forms according to whether the intercept, mean, lag coefficient and variance change with the state change. In...
As a key element of ocean circulation, the global meridional overturning circulation (MOC) affects the global climate by redistributing heat and influencing air-sea interactions (e.g., Msadek et al., 2013; Rose & Ferreira, 2013; Trenberth & Caron, 2001). MOC facilitates poleward meridional ...
(e.g., vital signs and clinical evaluation) (Supplementary Data1). Imaging data was collected for a random subset of patients to evaluate its impact on model performance (Supplementary Table1). All variables were pre-processed into features optimized for computation and were aggregated to hourly ...
principally MSA, is acknowledged. This is always a possibility in studies of recently diagnosed patients. We limited largely this false positive inclusion by studying only patients with very focal motor onset including resting tremor in a high proportion, and a correlatively focal dopaminergic loss ...