ALS is an example of motor neuron disease that causes neural degeneration over time leading to loss of muscle coordination. The common name is Lou Gehrig's disease after a baseball player diagnosed with the condition. The causes of this disease is unknown for the majority of individuals ...
Although in the PASADENA phase 2 study, the primary endpoint (Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) sum of Parts I + II + III) was not met, prasinezumab-treated individuals exhibited slower progression of motor signs than placebo-treated ...
Motor neuron disease/amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder characterised by loss of upper motor neurons (including the Betz cells of the motor cortex), and lower motor neuron, anterior horn cells of the spinal cord and brainstem nuclei. 5-10% in ALS ...
Although in the PASADENA phase 2 study, the primary endpoint (Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) sum of Parts I + II + III) was not met, prasinezumab-treated individuals exhibited slower progression of motor signs than placebo-treated ...
Alzheimer's Disease (AD) is considered one of the most diseases that much prevalent among elderly people all over the world. AD is an incurable neurodegenerative disease affecting cognitive functions and were characterized by progressive and collective f
objective of the study was to evaluate the safety and tolerability of tofersen which shows signs of potential efficacy in lowering the levels of the toxic SOD1 protein in the nervous system, something which will reduce damage in the nerve cells and help to slow the progression of symptoms." ...
Using spontaneous or warfarin-accelerated microvascular lesions, motor-neuron dysfunction and injury were found to be proportional to the degree of BSCB disruption at early disease stages in SOD1G93A mice. Early treatment with an activated protein C analog restored BSCB integrity that developed from ...
Importance In Huntington disease (HD) striatal neuron loss precedes and predicts motor signs or symptoms. Current imaging biomarkers lack adequate sensitivity for assessing the early stages of HD. Developing an imaging biomarker for HD spanning the time of onset of motor signs remains a major unmet...
Early-onset Alzheimer’s disease (EOAD) is a rare but particularly devastating form of AD. Though notable for its high degree of clinical heterogeneity, EOAD is defined by the same neuropathological hallmarks underlying the more common, late-onset form o
In addition, based on the fact that the motor symptoms and signs of PD are generally unilateral at the onset and show persistent asymmetry by primarily affecting the side of onset2,51, we defined the hemisphere contralat- eral to the initially symptomatic or more affected body side as the ...