To test this, a record of industry-sponsored phase II trials in asthma, COPD and Asthma/COPD over 11 years was obtained. The type of PE and the influence these had on length, number of subjects and investigational trial sites were evaluated for the different disease categories. Differences in...
Conclusion Adaptive design has shown an increasing use over the years, and was primarily applied to early phase drug trials. However, the reporting quality of adaptive trials is suboptimal, and substantial efforts are needed to improve the reporting.Peer...
Allergies, including asthma, food allergy and atopic dermatitis, are increasing in prevalence, particularly in westernized countries. Although a detailed mechanistic explanation for this increase is lacking, recent evidence indicates that, in addition to genetic predisposition, lifestyle changes owing to mo...
But in very serious cases, this phase could last for months. What are the symptoms of the newest COVID-19? Newer versions of COVID-19, like the Omicron strain EG.5, tend to infect the upper respiratory tract. Common symptoms of the new COVID-19 variants include a runny nose, sore ...
But in very serious cases, this phase could last for months. What are the symptoms of the newest COVID-19? Newer versions of COVID-19, like the Omicron strain EG.5, tend to infect the upper respiratory tract. Common symptoms of the new COVID-19 variants include a runny nose, sore ...
The lab is also working toward using inhalable sensors to distinguish between viral, bacterial, andfungal pneumonia. And the technology could also be used to diagnose other lung conditions likeasthmaandchronic obstructive pulmonary disease, Tan said. ...
an·a·phase (ăn′ə-fāz′) The stage of cell division in which the doubled set of chromosomes separates into two identical groups that move to opposite ends of the cell. In mitosis, anaphase is preceded by metaphase and followed by telophase. See more atmeiosis,mitosis. ...
Early infancy microbial and metabolic alterations affect risk of childhood asthma. Sci Transl Med. 2015;7(307):307ra152. Kostic AD, Gevers D, Siljander H, Vatanen T, Hyötyläinen T, Hämäläinen A-M, et al. The dynamics of the human infant gut microbiome in development and in...
The allergic early-phase reaction, a hallmark of allergic bronchial asthma, is caused by allergen and immunoglobulin E-dependent mediator release from mast cells. It was previously shown that nerve growth factor (NGF) contributes to acute airway inflammation. This study further investigates the role ...
An accelerated phase of foetal growth initiates at GD 197 in humans and GD 17 in mice, culminating in birth at GD 294 in humans and GD 21 in mice, marking the conclusion of the third trimester [46]. Changes in gestational timing can affect developmental exposure and outcomes, so timing ...