帕金森病(Parkinson Disease, PD)于1817年由英国医生James Parkinson首先描述,是一种缓慢进展的神经系统变性疾病,多见于中老年人。部分患者发病时年龄较小,称为早发性帕金森病(early-onset Parkinson Disease, EOPD),具有与典型PD不同的特点。Tanner等...
3) Idiopathic Parkinson Disease 特发性帕金森病 1. The Clinical Analysis of Orthostatic Hypotension in Idiopathic Parkinson Disease and Multiple System Atrophy with Orthostatic Hypotension and the Study of IPD-OH and MSA-OH by ～1H-MRS and DWI; 直立性低血压在特发性帕金森病和伴有直立性低血压的...
Early onset Parkinson's disease: are juvenile- and young-onset different? Mov Disord. 1994;9(5):539-544.Muthane U. B., Swamy H. S., Satishchandra P., Subhash M. N., Rao S. and Subbakrishna D. (1994) Early onset Parkinson's disease: are juvenile- and young-onset different? Mov...
“An Essay on the Shaking Palsy” in 1817. He isolated the symptoms of PD, although he wrongly believed it was due to lesions in the spine. Sixty years later, French neurologist Jean-Martin Charcot made the landmark discoveries about the disease and its rigidity and named it Parkinson’s d...
是的，pubmed有号 Neuropsychiatr Dis Treat. 2013;9:1067-9. doi: 10.2147/NDT.S48455. Epub 2013 Aug 2.A Case of early onset Parkinson's disease after major stress.Zou K, Guo W, Tang G, Zheng B, Zheng Z.SourceNeurobiological Laboratory, People's Republic of China.Abstract...
Parkinson’s disease (PD) is a neurodegenerative disease characterised by a progressive loss of dopaminergic neurons in the substantia nigra1. Diagnosis is predominantly based on the presentation of cardinal symptoms, including motor (such as bradykinesia and gait disturbances) and non-motor (sleep pro...
There are stable interactions among early-onset PSDS with Depressed mood, Psychiatric anxiety and Loss of interest as central symptoms. The strategic lesion locations for central symptoms may indirectly induce other PSDS via the symptom network, resulting in higher overall PSDS severity. Trial registr...
Background:Several studies have compared early-onset Parkinson disease (EOPD) and late-onset Parkinson disease (LOPD) but most are not based on autopsy confirmed cases.Methods:We compared clinical and pharmacological profiles, time to reach irreversible Hoehn and Yahr (H&Y) Stage 3 and levodopa mo...
Parkinson’s disease is a progressive (adj.逐步发生的) neurological (adj.神经病学的) disorder caused by the deaths of neurons in parts of the brain called the substantia nigra. Symptoms include loss of motor control, mood disturbance (n.干扰), ruined sleep and altered sense of smell. It is...
Therefore, to perform these examinations for subjects at risk for developing PD, early diagnosis before the onset of motor symptoms is becoming realistic.doi:10.1016/B978-0-12-815946-0.00018-1Yasuaki MizutaniYoshiki NiimiTatsuro MutohDiagnosis and Management in Parkinson's Disease...