Osteoporosis is a skeletal disorder with enhanced bone fragility, usually affecting the elderly. It is very rare in children and young adults and the defin
Another recently discovered form relates to disturbed sphingolipid metabolism due to SGMS2 mutations, underscoring the complexity of molecular pathology in monogenic early-onset osteoporosis. Management of young patients consists of treatment of secondary factors, optimizing lifestyle factors including calcium...
The initial fine-tuning processes are crucial for successful bone regeneration, as they guide skeletal stem cells through progenitor differentiation toward osteo- or chondrogenic fate. While fate determination processes are well-documented, the mechanism
Women who are experiencing the early onset of menopause may feel frustrated and confused, or fail to understand the changes in their bodies. They may wonde
as well as an impacted neurocognitive phenotype. Early initiation of a multidisciplinary treatment protocol during childhood and adolescents involving physical, speech, and occupational therapy as well as medical therapy including hormonal manipulation can help to minimize the physical and psychosocial impact...
(This question assumes that there is no disease curing treatment available, which there is not presently.) One of the unfortunate aspects of aging is bone loss. But not all older people develop osteoporosis. Discuss the difference between osteoporosis and...
Teriparatide Treatment in Patients With WNT1 or PLS3 Mutation-Related Early-Onset Osteoporosis: A Pilot Study. We previously identified 2 Finnish families with dominantly inherited, low-turnover osteoporosis caused by mutations in WNT1 or PLS3.This prospective, long... Ville-Valtteri,V?lim?ki,Out...
(B) Early onset PDB mutation. The 27-bp duplicated region is underlined. The region shown is from base 78 to base 104 in exon 1. lower limbs. Her left femoral neck fractured at 70 years old, but she did not receive any medical treatment and died at the age of 73. The propositus'...
Objective : An understanding of why certain factors contribute to a more rapid decline in ovarian function may, for some women, help prevent premature loss of fecundity and the subsequent impact of health problems secondary to long-term estrogen deficiency such as osteoporosis, cardiovascular disease,...
Treatment-emergent adverse event is defined as any adverse event with an onset date that is after the first dose of study drug, and no more than 30 days after the last dose of study drug. Data include patients receiving UPA or MTX monotherapy, censored at either time of rescue to UPA ...