We estimated volumes of hippocampal subfields on 7T MRI in normal aging and early Alzheimer's disease. We hypothesized that the subfields were differentially affected in normal cognition, subjective memory impairment, Mild Cognitive Impairment (MCI) and Alzheimer's disease....
MRI acquisition ADNI All ADNI subjects underwent a T1-weighted 3.0 T MRI scan using a MPRAGE (TR = 2300 ms, TE = 2.84–3.25 ms, TI = 900 ms, FA = 8°/9°) or a IR-SPGR (TR = 6.98–7.65 ms, TE = 2.84–3.20 ms, TI = 400 ms, FA = 11°) sequence. Scans using parallel...
MRI scans revealed that the NS group had a higher prevalence of abnormalities in the frontal lobes and/or the temporoparietal junction compared to the Non-NS group (24/25 vs. 13/19, P = 0.032). Conclusions The orienting and alerting functions but not executive function were ...
The authors would like to thank the following salaried employees of Eli Lilly and Company for their contributions to TRAILBLAZER-ALZ 2, for which they received no additional compensation: Andrea Abram, MBA; Hrideep Antony, BS; Anupa Arora, MD; Theresa Bauer, BS; Jude Burger, MS; Yang Dai,...
nurt., parental nurturance; PTSD, post-traumatic stress disorder; r, right; ROI, region of interest; S, splenium; SA, surface area; sup., superior; sMRI, structural magnetic resonance imaging; TBM, tensor-based morphometry; VBM, voxel-based morphometry; vm, volume; vPFC, ventral prefrontal...
Ivnik RJ Neuropsychological test performance as a function of the duration of MS-related symptomatology. J Clin Psychiatry.1978;39:304-307.Google Scholar 3. Marsh GG Disability and intellectual function in multiple sclerosis. J Nerv Ment Dis.1980;168:758-762.Google Scholar 4. Rao SMGlatt S...
normal aging, Gonneaud et al. elegantly paired advanced machine learning methods with functional imaging to predict chronologic age across the adult lifespan and subsequently showed that presymptomatic mEOAD cases demonstrate an MRI-predicted brain age greater than their chronologic age [134]. Building...
Estimates of white matter microstructure were quantified from the MRI scans collected when children were between 8 and 10 years of age (Figure 2). Findings revealed that institutional rearing was associated with reduced integrity of the body of the corpus callosum No significant intervention effect wa...
was then nonlinearly warped to subject’s mri using spm5 and the resulting deformation was applied to a brain anatomical atlas [ 28 ] consisting of 119 brain regions to obtain the brain region boundaries for each subject. this individualized atlas was used at a later stage to derive regional ...
Thirteen were excluded because of normal MRI and PET results. Because MTLE appears to be a progressive disorder,39 many patients with newly intractable limbic seizures, who might otherwise be considered surgical candidates, could have underlying lesions that cannot yet be identified on routine ...