Prenatal life and childhood represent periods that are vulnerable to environmental exposures. Both cold and heat may have negative impacts on children’s mental health and cognition, but the underlying neural mechanisms are unknown. Here, by a magnetic resonance imaging assessment of 2,681 children ...
Early congenital syphilis emerges in the first two years of life, and skin lesions are much like the secondary syphilides from the acquired syphilis: papular, papuloscuamous syphilides, deeply fissured papules of the mouth angles or the nostrils, condylomata lata (usually in the first year,...
It was to forestall any mistakes over her own identity that Cavendish, then widely known as the countess of Newcastle, published her autobiography in 1656: ... I verily believe some censuring Readers will scornfully say, why hath this Ladie writ her own Life? since none cares to know whose...
Quality of life was also measured using five-level EQ-5D (EQ 5D-5L) including both descriptive (index) and visual analogue scale (VAS) scores. The data were available for 323 patients (98.5%) at baseline and for 259 patients (86.3%) at 30-days. The baseline EQ-5D VAS score was 64....
Cell. Mol. Life Sci. https://doi.org/10.1007/s00018-019-03104-6 (2019). This outstanding, comprehensive review of human placental development focuses on stem cells and their use in understanding trophoblast lineage specification and commitment and is accompanied by instructive diagrams and ...
Encyclopedia of Quality of Life and Well-Being Research Magdalena Janus, Sally Brinkman & Martin Guhn 317 Accesses Definition The Early Development Instrument (EDI) is a population-based tool to measure developmental health of children at school entry in five major domains of child development: ...
Another important aspect of the socioemotional ecology of language learning in infancy is the shared dynamic between parents and infants in the context of life circumstances. For example, research suggests that the language trajectory of a young infant from a lower-income family with an inattentive ...
A life-threatening adverse event Inpatient hospitalisation or prolongation of existing hospitalisation: Admission for delivery or fetal monitoring, induction of labour or operative deliveries in which no fetal or maternal complication occurs will not be regarded as SAE. A disability/incapacity A congeni...
In humans, the thyroid gland becomes functional around 3 to 4 months of foetal life. Thus our exposure period corresponds to a period of human foetal development where only maternal thyroid hormone is available. In our model, the maternal thyroid hormone source is present in the yolk. Each ...
both within the context of academic research and for clinical and public health practice. This knowledge could enhance our understanding of the development of BMI trajectories, and can guide clinical and public health practice by highlighting early-life mechanisms occurring before BMI trajectories are ‘...