Brief cognitive screening tests performed by primary care physicians provide effective information for Alzheimer's patients and families regarding recent changes in daily living, behavior, intellectual functioning, and mood. In this review, we consider information in the literatureconcerning the practicality...
Early-onset Alzheimer’s disease, also called younger onset Alzheimer’s disease, is an uncommon form of dementia which affects individuals younger than the age of 65. Of all the people afflicted with Alzheimer’s disease, only an estimated five percent will develop symptoms at a younger age. ...
Keywords:Alzheimer’s Disease,Early Diagnosis,Genetic Biomarkers,Non Genetic Biomarkers,PET Probes Full-TextCite this paperAdd to My Lib Abstract: AD is the most common form of dementia among the aging population. The neuropathological alterations of AD are represented by the neurofibrillary tangles...
Inclusion criteria were as follows: ≥ 65 years; Mini-Mental Status Examination (MMSE, [50]) score 17–26; diagnosis of probable dementia based on comprehensive neuropsychological testing (Consortium to Establish a Registry for Alzheimer’s Disease [CERAD] test battery, [51]); ability to walk ...
Amyloid plaques associated with Alzheimer's disease (AD) induce inflammatory responses associated with activated microglia and reactive astrocytes, which exacerbate neurodegeneration through release of inflammatory cytokines, reactive oxygen species, and other factors. Inflammation contributes to neurodegeneration ...
Light sensitivity of the vertebrate retina relies on the integrity of photoreceptors, including rods and cones. Research in patients with Alzheimer's disease (AD) and in AD transgenic mice reports that accumulated amyloid-β (Aβ) plaques in the retina are toxic to retinal neurons. Moreover, A...
The rapid development of metabolomics is inextricably linked to advancements in its technology. Liquid chromatography (LC) and gas chromatography (GC) are the most prevalent methods for metabolite separation, while metabolite detection primarily relies on nuclear magnetic resonance (NMR) and mass spectrome...
of Alzheimer’s disease, before synapses or neurons are lost, is suggested by the fact that the reduction of cerebral blood flow starts early in preclinical AD [107,180], with a faster onset than the deposition of Aβ or tau [76], and the fall of metabolism is also an early event [...
Surprisingly, abolishment of C3+-astrocyte formation by knocking out TNF-α, IL-1α and C1qa accelerated the prion disease course. Very recent investigations in mouse models of tauopathies and Alzheimer’s disease suggested regulation of the complement 3 receptor (C3aR), that is abundant on ...
of serum and plasma proteins, and extended its impact in biomedical and clinical studies19. Data independent acquisition based MS (DIA-MS) could effectively avoid the masking effect of high abundance proteins (HAP) on low abundance proteins (LAP), and improve detection efficiency and sample ...