髓鞘少突胶质细胞糖蛋白(MOG35-55)和完全弗氏佐剂(CFA)免疫诱导6-8周龄健康雌性小鼠,诱导当天为第0天。(PTX: 百日咳毒素) 验证数据 Figure 1: MOG35-55induced EAE model in C57BL/6 (A) body weight (B) clinical score (n=5). Figure 2: MOG35-55induced EAE model in C57BL/6 (A) typical pat...
We assess the severity of MS through EAE clinical score system. We quantitatively assess lymphocyte infiltration, demyelination and axonal damage by Histopathological techniques. We use SPECT/CT to detect inflammation in the brain and spinal cord. Assays available Histopathological evaluation SPECT/CT moni...
Chronic immobil- isation stress ameliorates clinical score and neuroinflammation in a MOG-indueed EAE in Dark Agouti rats: mechanisms tm- plicated[J]. J Neuroinflammation, 2010, 7.. 60.Perez-Nievas BG, Garcia-Bueno B, Madrigal JL, Leza JC. Chronic immobilisation stress ameliorates clinical ...
A clinical score of 3 was predefined as a study endpoint. Animals #8 and #9 were treated with prednisolone for 5 days as part of a concurrent study [38]. These animals were the first within their twin pair that showed three or more brain lesions by in vivo MRI and received ...
A clinical score of 3 was predefined as a study endpoint. Animals #8 and #9 were treated with prednisolone for 5 days as part of a concurrent study [38]. These animals were the first within their twin pair that showed three or more brain lesions by in vivo MRI and received ...
wereobserved.Threeclinicalassessmentmethods,including5- point,7-pointand15-point,wereusedtoassessneurological function.Results:Ontheearlyonset,7-point,the15-pointdisease scorescalesweremoresensitivitythan5-pointscorescaletothe incidenceofdisease.Andthe15-pointdiseasescorescalewas stronglycorrelatedwithpathological...
Therefore,the 15-point disease score scale is recommended as the fit method to select. Key words: experimental autoimmune encephalomyelitis ;animal model;mice ;clinical as-sessment 实验性自身免疫性脑脊髓炎(experimental autoimmune encephalomyelitis,EAE)模型是国际公认的多发性硬化(multiple sclerosis,MS)动物...
Caffeine counteracts the disease-prone potential of high sucrose in EAE. (a) Coca-Free was replenished with caffeine (0.1 mg ml−1) and used for treatment of mice for 8 weeks before immunization. The clinical score was assessed and shown.n=8. (b) Caffeine (0.1 mg ml−1...
Therefore,the 15-point disease score scale is recommended as the first method to select. Key words: experimental autoimmune encephalomyelitis ;animal model;mice ;clinical as-sessment 实验性自身免疫性脑脊髓炎模型是国际公认的多发性硬化(multiple sclerosis,MS)动物模型,被广泛用于MS发病机制和评价免疫调节...
The EAE model in Lewis rats has consistent disease onset and severity, as well as a short clinical course, making it a popular compound screen for potential efficacy in MS.EAE in Lewis rats is characterized by paralysis and CNS inflammation. Demyelination is not typically observed. EAE is ...