文中列举了EGFR 19del变异的所有亚型(图1),按氨基酸缺失起始位置分,发现相比L747del亚型(从L747位置缺失),E746del亚型(从E746位置缺失)具有更长的OS、更长的PFS和更高的T790M获得性突变率,尤以E746_A750del最为显著。 图1. EGF...
1. Le-Tian Huang, Shu-Ling Zhang, Cheng-Bo Han, et al. Impact of EGFR Exon 19 Deletion Subtypes on Clinical Outcomes in EGFR-TKI-Treated Advanced Non-Small-Cell Lung Cancer. Lung Cancer, Volume 166, 2022, Pages 9-...
The most frequent exon 19 deletion is E746-A750, accounting for 90% of lesions at this site, although some rare variants occur. Lynch, T.J. et al. (2004) N Engl J Med 350, 2129-39. Pao, W. et al. (2004) Proc Natl Acad Sci USA 101, 13306-11. Haber, D.A....
基因名:EGFR 别名:ERBB,ERBB1,HER1,NISBD2,PIG61,mENA 基因ID:1956 Chromosome: (GRCh37)7Start:55086714End:55324313Strand:1 药物:氟尿嘧啶AEE788阿法替尼贝伐单抗,贝伐珠单抗博舒替尼布加替尼 布格替尼 布吉他滨帕尼单抗西妥昔单抗卡奈替尼顺铂克唑替尼CRS/IPHC达可替尼 达克替尼多西他赛EGFR Inhibitor厄洛替...
Description EGFR E746_A750del results in the deletion of five amino acids in the kinase domain of the Egfr protein from amino acids 746 to 750 (PMID: 17318210). E746_A750del results in increased Egfr kinase activity, activation of p44/42 MAPK and AKT in cell culture, promotes tumor growth...
Here, we showed that in the clinic, LC with the E746-A750 deletion mutation (EGFR-19del) displayed a temporal association with the loss of intratumoral CD8+ T cells. In a xenograft model, EGFR-19del-expressing Lewis lung cancer (LLC) tumors had a low T cell density at the early stage...
Immunohistochemical detection of (A) EGFR exon 19 E746-A750 deletion, and (B) exon 21 L858R point mutation.doi:10.1371/journal.pone.0043842.g003Angulo BarbaraC. EstherSuárez-Gauthier AnaPlaza CarlosM. RebecaRedondo PilarIzquierdo ElisaR. Belén...
EGFR E746-A750 deletion antibody 中文名: 中文别名: CBNumber: CB85728945 分子式: 分子量: 0 MOL File: Mol file 化学性质安全信息用途供应商6 EGFR E746-A750 deletion antibody化学性质 安全信息 EGFR E746-A750 deletion antibody性质、用途与生产工艺 ...
Detection of EGFR exon 19 E746-A750 deletion and EGFR exon 21 point mutations in lung adenocarcinoma by immunohistochemistry: a comparative study to EGFR ... D Chabot-Richards,K Buehler,MA Vasef - 《Journal of Histotechnology》 被引量: 0发表: 2015年 Immunohistochemical detection of mutated epider...
EGFR PE746A750del（EGFR L747_A750del）是一种肿瘤变异。EGFR是表皮生长因子受体（Epidermal Growth Factor Receptor）的简称，肺癌患者中约有10-15%存在该基因变异。该突变与EGFR基因的缺失部分有关，这将导致EGFR蛋白质中区域的缺失。EGFR PE746A750del常常与肺癌的发生有关，其出现使得Tyr1068的激活...