Some studies now link the pathway dysfunction of the EVs to apolipoprotein E gene variant (APOE ε4) and the risk of progression to Alzheimer's disease (AD). To better understand the role of APOE ε4 in pre-clinical AD, we have determined levels of pathogenic, neurotrophic and inflammatory...
Background: The apolipoprotein E (APOE) 系4 allele is a common Alzheimer's disease (AD) susceptibility gene. Previously, sleepiness was negatively correlated with memory in an exploratory cross-sectional study of cognitively normal APOE-... CM Stonnington,PJ Snyder,JG Hentz,... - 《Alzheimers ...
APOE ε4 is a strong risk variant for AD, and in patients carrying this allele oligomeric Aβ has enhanced synaptic localisation alongside higher oligomeric Aβ burden and synapse loss [64]. APOEε4 has also been shown to selectively impair glutamate activity and NMDA receptor phosphorylation via...
Three common alleles in the APOE gene, E2/E3/E4, have been associated with lipoprotein disorders but their effects on myocardial infarction (MI) risk ... S Liu,J Ma,PM Ridker,... - 《Atherosclerosis》 被引量: 113发表: 2003年 A prospective study of the association between APOE genotype...
Methods: Functional alleles in the serotonin transporter gene SLC6A4 were evaluated in TD probands, relatives and controls (total European ancestry N ¼ 1284). We genotyped the 5-HTTLPR, rs25531, rs25532 and the rare gain-of-function SERT I425V variant. Results: The higher-expressing 5-...
cases of HLPP3 have also been observed in individuals heterozygous for rare APOE variants. The influence of APOE on lipid levels is often suggested to have major implications for the risk of coronary artery disease (CAD). Individuals carrying the common APOE*4 variant are at higher risk of ...
Apo E also plays an important role in the formation of very low density lipoprotein and chylomicrons. The Apo E gene is located on chromosome 19 at position 19q13. 2. 仅用于科研。不用于诊断过程。未经明确授权不得转售。生物信息学 蛋白别名: Apo-E; ApoE4; Apolipoprotein; Apolipoprotein E; ...
The most significant genetic risk factor for late onset Alzheimer's disease is a variant of the apolipoprotein E gene, APOE4. Here we show that the single nucleotide polymorphism rs429358 that defines APOE4 is located in a short sequence motif repeated several times within exon 4 of ...
Using human APOE gene replacement mice as models, this study showed that apoE2 and apoE4 expressed endogenously in myeloid cells enhanced the inflammatory response via mechanisms independent of plasma lipoprotein transport. The data revealed that apoE2-expressing myeloid cells contained higher ...
The major variant of AD is late-onset AD (LOAD), which usually affects patients with an age higher than 65 years (Haass and Selkoe2007; Huang and Mucke2012). Although a number of genetic and environmental risk factors have been described for LOAD, the expression of theAPOE4allele is the ...