[20] Xu G,Livingston JA,Krek W.Multiple members of the E2F transcription factor family are the products of oncogenes.Proc Natl Acad Sci USA,1995;92:1357-1361 [21] Yang XH,SiadeK TL.Overexpression of the E2F-1 transcription factor gene mediates cell transformation.Gene Expr,1995,4:195-204....
2006. CDCA4 Is an E2F transcription factor family-induced nuclear factor that regulates E2F-dependent transcriptional activation and cell proliferation. J Biol Chem 281(47):35633-35648.Hayashi R, Goto Y, Ikeda R, Yokoyama KK, Yoshida K (2006) CDCA4 is an E2F transcription factor family-...
family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within ...
The retinoblastoma tumor suppressor, pRb, restricts cell-cycle progression mainly by regulating members of the E2F-transcription-factor family. The Rb pathway is often inactivated in human tumors, resulting in deregulated-E2F activity that promotes proliferation or cell death, depending on the cellular ...
Atypical E2Fs: new players in the E2F transcription factor family. Trends Cell Biol. 19, 111–118 (2009). 5. Chen, H. Z., Tsai, S. Y. & Leone, G. Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat. Rev. Cancer 9, 785–797 (2009). 6. Chen, H. Z....
The E2F family of transcription factors has been implicated in the regulation of cell proliferation, and E2F-binding sites are present in the promoters of several growth-regulating genes. E2F family members are functionally regulated, in part, by complex formation with one or more members of the ...
family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within ...
Veylder, Atypical E2Fs: new players in the E2F transcription factor family Trends Cell Biol., 19 (3) (2009), pp. 111-118 View PDFView articleView in ScopusGoogle Scholar [94] L.N. Kent, G. Leone The broken cycle: E2F dysfunction in cancer Nat. Rev. Cancer, 19 (6) (2019), pp...
We propose that the availability of many replication components together, regulated by the E2F family of transcription factors, determine the replication capacity of a cell, which, depending on the number of active replication forks, limits fork speed. This is consistent with the observations that ...
The E2F transcription factor family is traditionally associated with cell cycle control. However, recent data has shown that activating E2Fs (E2F1-3a) are potent activators of apoptosis. In contrast, the recently cloned inhibitory E2Fs (E2F7 and 8) appear to antagonize E2F-induced cell death. ...