HP537片是公司独立自主研发的p300/CBP(E1A-binding protein P300/CREBbinding protein, p300/CBP)抑制剂小分子抗肿瘤药物,HP537片通过结合 p300/CBP溴结构域(bromine domain, BRD)阻断p300/CBP信号通路。p300/CBP参 与细胞周期进展和细胞生长、分化和发展,在肿瘤中高度表达和激活,是肿瘤细 胞生长的关键调控因子。H...
CREB binding protein (CREBBP; CBP); E1A binding protein p300 (EP300; p300); hypoxia-inducible factor 1|[alpha]| (HIF1A; HIF1|[alpha]|)In vitro and mouse studies suggest peptide inhibitors of HIF1A could help treat cancer. Further details on the research, next steps and licensing status...
We recently showed that p300/CREB-binding protein (CBP) plays an important role in maintaining cells in G0/G1phase by keeping cin a repressed state. Consistent with this, adenovirus E1A oncoprotein induces cin a p300-dependent manner, and the cinduction is linked to S-phase induction. The ...
The adenovirus-transforming protein E1A is acetylated by its cellular targets, the co-activators CREB-binding protein, p300, and p300/CREB-binding protein-associated factor in vitro and also in vivo at a single lysine residue (Lys239) within a multifunctional carboxyl-terminal domain necessary for...
E1a failed to enhance cAMP-stimulated transcription from promoters containing mutations that abolish binding by cAMP response element binding protein (CREB) or CCAAT/enhancer binding proteins (C/EBPs). This result was supported by experiments in which expression of dominant-negative CREB and/or C/...
This region of E1A binds multiple transcriptional regulators, including the p300, CBP (CREB Binding Protein) and pCAF acetyltransferases, TBP, TRRAP and p400 [27]. Paradoxically, this region functions as a transcriptional repression domain in the context of the E1A 243R protein by sequestering ...
CREB-binding protein During the mid to late G1 phase of the cell cycle, the mammalian cell encounters a critical point where an irrevocable commitment takes place to either enter replicative DNA synthesis or to withdraw from the cell cycle with an unduplicated genome. This critical G1 checkpoint...
CBP (CREB-binding protein) is a transcriptional coactivator of CREB (cAMP response element-binding) protein, which is directly phosphorylated by PKA (cAMP-... Dai,Akimaru,Tanaka,... - 《Genes & Development》 被引量: 614发表: 1996年 Interferon Consensus Sequence Binding Protein–deficient Mice ...
p300, which was originally cloned as a nuclear binding target of the adenovirus E1A oncoprotein, forms a family with cyclic-AMP response element binding protein (CREB)-binding protein (CBP). p300/CBP are considered to be transcriptional coactivators that connect the basal transcriptional machinery to...
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