forthe degree ofMaster 98692 Researchon Methylation ofTIMP3andE-・cadherinGenes in Esophageal CarcinomaCellLines By XuanZhao Supervisor:Prof.ZimingDong Pathology and Pathophysiology College ofBasicMedicalScience June2010 师的指导下,独立进行研究所取 得的成果。除文中已经注明引用的内容外,本论文不包含任何...
A gene on chromosome 16q22.1 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells. Molecular pathology CDH1 loss-of-function mutations correlate with gastric, breast, colorectal,...
5 Tamura G.Yin J,Wang S,et a1.E—Cadherin gene promoter hy- IJermethylation in plima黟htnnan gas—c Natl CarI— Celt"lnst.200lo.92:569—573. 6 Azarschab P,Porschen R,Gregor M,et a1.Epigenetic control of the E—cadherin geae(CDHl)by cr,c;methylatk'n in eolectomy s∞_ples ...
eliminatinggene metastasis achievethe oftreatmentof it be growth,to purpose tumor,thereforemay thenew fortumor target therapy. Objective: weaimedtoobserveE—cardherin statewhether genepromotermethylation andunderstandthe ofinvasionandmetastasis reverseand to change re.expression, of carcinomaafter E-card...
The transcriptional factor Snail1 is a repressor of E-cadherin (CDH1) gene expression that acts by binding directly to the E-cadherin promotor42. This process requires EZH2-mediated trimethylation of H3K2742. However, cisplatin-induced trimethylation of H3K27 was not inhibited by 3-DZNeP in ...
14 Oliveira C, Seruca R, Hoogerbrugge N, Ligtenberg M, Carneiro F: Clinical utility gene card for: hereditary diffuse gastric cancer (HDGC). Eur J Hum Genet 2013; 21: doi:10.1038/ejhg.2012.247. 15 Kellermayer R: Translational readthrough induction of pathogenic nonsense mutations. Eur J ...