Patients with colorectal cancer (CRC) harboring BRAF mutation have a poor prognosis. The median survival time for patients with advanced BRAFV600E-mutant CRC is only approximately one year. Owing to the insensitivity to standard chemotherapy, there are s
Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintenance of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. ...
Point Mutation Conditional Point Mutation Humanization Targeted Conditional Overexpression Random Transgene Surgery & Preconditioning Surgery Preconditioning Therapeutic Area Oncology Syngeneic Models GEMM-Derived Allografts Humanized Mice CDX Models PDX Models Humanized Drug Target IO Mice ...
Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintenance of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. ...
Braun A, Kammerer S, Cleve H, Löhrs U, Schwarz HP, Kuhnle U (1993) True hermaphroditism in a 46,XY individual, caused by a postzygotic somatic point mutation in the male gonadal sex-determining locus (SRY): molecular genetics and histological findings in a sporadic case. Am J Hum Gene...
human WB Cancer Res Efficacious immune therapy in chronic myelogenous leukemia (CML) recognizes antigens that are expressed on CML progenitor cells. Authors - Biernacki Melinda A MA View Article mouse IHC Exp Neurol Mutation of the TBCE gene causes disturbance of microtubules in the auditory nerve...
Applications WB, IHC-P, IF Clonality Rabbit Monoclonal Immunogen A synthetic peptide of human E Cadherin Abbre E Cadherin Synonyms Arc 1, CADH1, CAM 120/80, CD 324, CD324, CD324 antigen, CDHE, Cadherin 1, Cadherin1, E-Cad/CTF3, E-cadherin, ECAD, Epithelial cadherin, LCAM, Liver ...
mouse WB Cell Rep Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly. Authors - Oliver Rackham View Article human WB Hum Mol Genet Leber's hereditary optic neuropathy (LHON)-associated ND6 14 484 T > C mutation caused pleiotropic effects on the complex I, RNA home...
Applications: Western Blotting (WB) Reactivity: Unspecified Title: DOCK8 gene mutation alters cell subsets, BCR signaling, and cell metabolism in B cells. Author: Heng Gu, et. al. Year: 2024 Journal: J Biochem Mol Toxicol Applications: Unspecified Reactivity: Unspecified Title: Mincle Maintains...
货号:0407-25 Cadherin-1 或上皮钙黏蛋白 (E-cadherin) 是一种由 CDH1 基因编码的蛋白质。其突变与胃癌、乳腺癌、结直肠癌、甲状腺癌和卵巢癌相关。CDH1 也被指定为 CD324(分化簇 324),是一种肿瘤抑制基因。Cadherin-1 是钙黏蛋白超家族的经典成员,其编码的蛋白质是一种钙依赖性细胞间黏附糖蛋白,由五个...