Immunosuppressive Properties and Side Effects of E. Coli L-AsparaginaseThe immunosuppressive properties of L-Asparaginase (L-Ase) were studied by different test systems. First we tested the inhibition of the cellular immun-reaction after immunization of mice with sheep red blood cells by means of counting the "rosettes" forming...
42 Combining different cytokine-secreting cells in the Myo-P device could lead to effective cytokine therapy, without requiring high-dose infusions that can result in anti-drug antibodies and/or systemic side effects that limit long-term benefits.43 This technology could also improve the synergy ...
Little is known about the risk of invasive E. coli disease (IED) after elective urologic procedures. We estimated the risk of IED after selected urologic p
coli. epistasis Non-reciprocal interaction of non-allelic genes – for example when the expression of one gene masks the expression of another. Thus a gene that blocks development of an organ will mask the effects of genes that would modify the form of that organ had it been developed. epi...
We usedE. coliNissle 1917 (EcN) as our cellular chassis for PATCH. EcN is well-studied, has a long track record of safety in humans, and is a popular starting point for engineered therapeutic microbe efforts because of its compatibility with canonical genetic engineering techniques for bacteria...
coli (APEC) strains and virulence genes (ibeA, hlyA, iss, pap C and ompA) was applied to study the therapeutic effect of zinc and copper nanoparticles to be used as an antibiotic alternative (Nanobiotic). Furthermore, the in-vivo effects of CuNPs were evaluated. Additionally, the CuNPs ...
coli entering into stationary phase but also maintains it during exponential phase growth following sub-culture into fresh medium the next day. This phenomenon, which we term the “pH cycle” is illustrated in Fig. 5. Figure 5 The pH Cycle. A schematic diagram of two consecutive growth cycles...
Infec- tions were classified as community-acquired healthcare- associated infections if any of the following criteria were met: Living in a long-term care facility or nursing home, receiving outpatient intravenous therapy within the past 30 days, attending a hospital or hemodialysis clinic within ...
is not sustainable in the long term. Taken together, these arguments represent a valid motivation for the implementation of recombinant protein expression approaches independent of antibiotics [11,12,13,14,15,16]. Recently, a new complementation concept has been proposed that should overcome the limi...
As used herein, the term iss or iss "gene" refers to a nucleic acid sequence or molecule that encodes an avian E. coli Iss polypeptide. Thus, the present invention provides an isolated and purified nucleic acid molecule that encodes an avian E. coli Iss polypeptide, a biologically active ...