DYT5mutations may cause dopa-responsive dystonia (DRD), which is also called Segawa’s disease. Symptoms usually start in childhood and tend to worsen after physical activity as well as later in the day. DRD symptoms can often be well-controlled with levodopa (Sinemet), which is also used t...
In primary (isolated) dystonia the dystonic symptoms, which reflect the impairment of the motor system function, are the only disease's manifestation. Primary dystonia is the most prevalent form of dystonia syndrome, with a prevalence of about 16 per 100,000 in general population (Steeves, Day,...
Publication » V12 Poster location 012 Deep brain stimulation in PKAN patients with dystonia symptoms.doi:10.1016/S1090-3798(09)70032-7T. K. KmiecT. M. MandatH. K. KoziaraW. L. LibionkaH. P. ProkischElsevier LtdEuropean Journal of Paediatric Neurology...
美 英[dɪs'təʊnɪə] n.肌张力障碍;肌紧张不足;进行性脊柱前凸性步行困难 网络肌张力不全;肌张力异常;肌张力不全症 英汉 英英 网络释义 n. 1. 肌张力障碍 2. 肌紧张不足 3. 进行性脊柱前凸性步行困难
The underpinnings of a supposed basal ganglia pathway imbalance in dystonia are unknown. Here, the authors unveil exaggerated low frequency coupling in the direct striato-pallidal pathway to reflect dystonic symptoms, which could potentially be used as target for neuromodulation strategies. Roxanne Lof...
"Spinal circuit dysfunction is rarely considered in movement disorder research, but the symptoms of these conditions are largely produced by neurons resident within thespinal cord. To this end, while DYT1 dystonia is a relatively rare condition, our findings could also be important not only for th...
“I learn from them. They are my best sources of information. I see the patterns in their symptoms and accumulate information. My patients are my teachers.” To explain their conditions, he often mimics their behavior. “Some patients, they walk around like this, like a bulldog,” Truong ...
Dementia is not a specific disease; it is a broad term that characterizes many different conditions, such as Alzheimer’s disease, vascular dementia, frontotemporal dementia, and other disorders. Dementia refers to a group of symptoms that can be caused by several different brain disorders. ...
Symptomatic animal models have clinical features consistent with human disorders and are often used to identify the anatomical and physiological processes involved in the expression of symptoms and to experimentally demonstrate causality where it would be infeasible in the patient population. Rodent and pri...
When do symptoms occur? In some individuals, symptoms of a dystonia appear in childhood, approximately between the ages of 5 and 16, usually in the foot or in the hand. In generalized dystonia, the involuntary dystonic movements may progress quickly to involve all limbs and the torso, but th...